SafetyEthicsAccountabilitycs.CL
AI Safety Training Can be Clinically Harmful
Suhas BN, Andrew M. Sherrill, Rosa I. Arriaga, Chris W. Wiese, Saeed Abdullah
April 25, 2026
arXiv.org
1 citations
Key Takeaways
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Most AI mental health chatbots lack clinical testing: Only 16% of LLM-based mental health chatbots have undergone rigorous clinical efficacy testing, yet simulations show psychological deterioration in over one-third of cases, raising serious questions about deployment at scale without proper validation.
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AI safety training creates a dangerous paradox: The very safety measures designed to protect users (like refusing to engage with self-harm content) actually undermine evidence-based therapies like Prolonged Exposure and Cognitive Behavioral Therapy, causing models to abandon therapeutic protocols or offer false reassurance when patients need to confront difficult thoughts.
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Performance collapses under realistic conditions: While AI models appear competent at surface-level responses (91-100% accuracy), their therapeutic appropriateness drops dramatically to 22-33% when handling severe cases, and protocol fidelity reaches zero for two of four models tested—meaning they fail to follow established clinical guidelines.
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Current AI evaluation methods are insufficient: Standard AI safety metrics don't capture whether a system is actually helping or harming patients; the authors propose a new five-axis framework (protocol fidelity, hallucination risk, behavioral consistency, crisis safety, demographic robustness) aligned with FDA and EU regulatory requirements.
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Responsible deployment requires clinical expertise, not just AI expertise: Developing safe AI mental health tools demands collaboration between AI researchers and clinical psychologists to ensure safety measures don't sabotage therapeutic effectiveness—a gap that currently exists in most AI development.