Research Papers

Exploring Explainable AI Techniques for Improved Interpretability in Lung and Colon Cancer Classification

Mukaffi Bin Moin, Fatema Tuj Johora Faria, Swarnajit Saha +2

Lung and colon cancer are serious worldwide health challenges that require early and precise identification to reduce mortality risks. However, diagnosis, which is mostly dependent on histopathologists' competence, presents difficulties and hazards when expertise is insufficient. While diagnostic methods like imaging and blood markers contribute to early detection, histopathology remains the gold standard, although time-consuming and vulnerable to inter-observer mistakes. Limited access to high-end technology further limits patients' ability to receive immediate medical care and diagnosis. Recent advances in deep learning have generated interest in its application to medical imaging analysis, specifically the use of histopathological images to diagnose lung and colon cancer. The goal of this investigation is to use and adapt existing pre-trained CNN-based models, such as Xception, DenseNet201, ResNet101, InceptionV3, DenseNet121, DenseNet169, ResNet152, and InceptionResNetV2, to enhance classification through better augmentation strategies. The results show tremendous progress, with all eight models reaching impressive accuracy ranging from 97% to 99%. Furthermore, attention visualization techniques such as GradCAM, GradCAM++, ScoreCAM, Faster Score-CAM, and LayerCAM, as well as Vanilla Saliency and SmoothGrad, are used to provide insights into the models' classification decisions, thereby improving interpretability and understanding of malignant and benign image classification.

Industry is at the forefront of adopting new technologies, and the process followed by the adoption has a significant impact on the economy and society. In this work, we focus on analysing the current paradigm in which industry evolves, making it more sustainable and Trustworthy. In Industry 5.0, Artificial Intelligence (AI), among other technology enablers, is used to build services from a sustainable, human-centric and resilient perspective. It is crucial to understand those aspects that can bring AI to industry, respecting Trustworthy principles by collecting information to define how it is incorporated in the early stages, its impact, and the trends observed in the field. In addition, to understand the challenges and gaps in the transition from Industry 4.0 to Industry 5.0, a general perspective on the industry's readiness for new technologies is described. This provides practitioners with novel opportunities to be explored in pursuit of the adoption of Trustworthy AI in the sector.

With the upcoming AI regulations (e.g., EU AI Act) and rapid advancements in generative AI, new challenges emerge in the area of Human-Centered Responsible Artificial Intelligence (HCR-AI). As AI becomes more ubiquitous, questions around decision-making authority, human oversight, accountability, sustainability, and the ethical and legal responsibilities of AI and their creators become paramount. Addressing these questions requires a collaborative approach. By involving stakeholders from various disciplines in the 2\textsuperscript{nd} edition of the HCR-AI Special Interest Group (SIG) at CHI 2024, we aim to discuss the implications of regulations in HCI research, develop new theories, evaluation frameworks, and methods to navigate the complex nature of AI ethics, steering AI development in a direction that is beneficial and sustainable for all of humanity.

LangXAI is a framework that integrates Explainable Artificial Intelligence (XAI) with advanced vision models to generate textual explanations for visual recognition tasks. Despite XAI advancements, an understanding gap persists for end-users with limited domain knowledge in artificial intelligence and computer vision. LangXAI addresses this by furnishing text-based explanations for classification, object detection, and semantic segmentation model outputs to end-users. Preliminary results demonstrate LangXAI's enhanced plausibility, with high BERTScore across tasks, fostering a more transparent and reliable AI framework on vision tasks for end-users.

Polysemantic neurons -- neurons that activate for a set of unrelated features -- have been seen as a significant obstacle towards interpretability of task-optimized deep networks, with implications for AI safety. The classic origin story of polysemanticity is that the data contains more ``features" than neurons, such that learning to perform a task forces the network to co-allocate multiple unrelated features to the same neuron, endangering our ability to understand networks' internal processing. In this work, we present a second and non-mutually exclusive origin story of polysemanticity. We show that polysemanticity can arise incidentally, even when there are ample neurons to represent all features in the data, a phenomenon we term \textit{incidental polysemanticity}. Using a combination of theory and experiments, we show that incidental polysemanticity can arise due to multiple reasons including regularization and neural noise; this incidental polysemanticity occurs because random initialization can, by chance alone, initially assign multiple features to the same neuron, and the training dynamics then strengthen such overlap. Our paper concludes by calling for further research quantifying the performance-polysemanticity tradeoff in task-optimized deep neural networks to better understand to what extent polysemanticity is avoidable.

Big models have greatly advanced AI's ability to understand, generate, and manipulate information and content, enabling numerous applications. However, as these models become increasingly integrated into everyday life, their inherent ethical values and potential biases pose unforeseen risks to society. This paper provides an overview of the risks and challenges associated with big models, surveys existing AI ethics guidelines, and examines the ethical implications arising from the limitations of these models. Taking a normative ethics perspective, we propose a reassessment of recent normative guidelines, highlighting the importance of collaborative efforts in academia to establish a unified and universal AI ethics framework. Furthermore, we investigate the moral inclinations of current mainstream LLMs using the Moral Foundation theory, analyze existing alignment algorithms, and outline the unique challenges encountered in aligning ethical values within them. To address these challenges, we introduce a novel conceptual paradigm for aligning the ethical values of big models and discuss promising research directions for alignment criteria, evaluation, and method, representing an initial step towards the interdisciplinary construction of the ethically aligned AI This paper is a modified English version of our Chinese paper https://crad.ict.ac.cn/cn/article/doi/10.7544/issn1000-1239.202330553, intended to help non-Chinese native speakers better understand our work.

Current anti-spoofing and audio deepfake detection systems use either magnitude spectrogram-based features (such as CQT or Melspectrograms) or raw audio processed through convolution or sinc-layers. Both methods have drawbacks: magnitude spectrograms discard phase information, which affects audio naturalness, and raw-feature-based models cannot use traditional explainable AI methods. This paper proposes a new approach that combines the benefits of both methods by using complex-valued neural networks to process the complex-valued, CQT frequency-domain representation of the input audio. This method retains phase information and allows for explainable AI methods. Results show that this approach outperforms previous methods on the "In-the-Wild" anti-spoofing dataset and enables interpretation of the results through explainable AI. Ablation studies confirm that the model has learned to use phase information to detect voice spoofing.

Collect, Measure, Repeat: Reliability Factors for Responsible AI Data Collection

Oana Inel, Tim Draws, Lora Aroyo

The rapid entry of machine learning approaches in our daily activities and high-stakes domains demands transparency and scrutiny of their fairness and reliability. To help gauge machine learning models' robustness, research typically focuses on the massive datasets used for their deployment, e.g., creating and maintaining documentation for understanding their origin, process of development, and ethical considerations. However, data collection for AI is still typically a one-off practice, and oftentimes datasets collected for a certain purpose or application are reused for a different problem. Additionally, dataset annotations may not be representative over time, contain ambiguous or erroneous annotations, or be unable to generalize across issues or domains. Recent research has shown these practices might lead to unfair, biased, or inaccurate outcomes. We argue that data collection for AI should be performed in a responsible manner where the quality of the data is thoroughly scrutinized and measured through a systematic set of appropriate metrics. In this paper, we propose a Responsible AI (RAI) methodology designed to guide the data collection with a set of metrics for an iterative in-depth analysis of the factors influencing the quality and reliability} of the generated data. We propose a granular set of measurements to inform on the internal reliability of a dataset and its external stability over time. We validate our approach across nine existing datasets and annotation tasks and four content modalities. This approach impacts the assessment of data robustness used for AI applied in the real world, where diversity of users and content is eminent. Furthermore, it deals with fairness and accountability aspects in data collection by providing systematic and transparent quality analysis for data collections.

Interpretable part-prototype models are computer vision models that are explainable by design. The models learn prototypical parts and recognise these components in an image, thereby combining classification and explanation. Despite the recent attention for intrinsically interpretable models, there is no comprehensive overview on evaluating the explanation quality of interpretable part-prototype models. Based on the Co-12 properties for explanation quality as introduced in arXiv:2201.08164 (e.g., correctness, completeness, compactness), we review existing work that evaluates part-prototype models, reveal research gaps and outline future approaches for evaluation of the explanation quality of part-prototype models. This paper, therefore, contributes to the progression and maturity of this relatively new research field on interpretable part-prototype models. We additionally provide a ``Co-12 cheat sheet'' that acts as a concise summary of our findings on evaluating part-prototype models.

In the context of sixth-generation (6G) networks, where diverse network slices coexist, the adoption of AI-driven zero-touch management and orchestration (MANO) becomes crucial. However, ensuring the trustworthiness of AI black-boxes in real deployments is challenging. Explainable AI (XAI) tools can play a vital role in establishing transparency among the stakeholders in the slicing ecosystem. But there is a trade-off between AI performance and explainability, posing a dilemma for trustworthy 6G network slicing because the stakeholders require both highly performing AI models for efficient resource allocation and explainable decision-making to ensure fairness, accountability, and compliance. To balance this trade off and inspired by the closed loop automation and XAI methodologies, this paper presents a novel explanation-guided in-hoc federated learning (FL) approach where a constrained resource allocation model and an explainer exchange -- in a closed loop (CL) fashion -- soft attributions of the features as well as inference predictions to achieve a transparent 6G network slicing resource management in a RAN-Edge setup under non-independent identically distributed (non-IID) datasets. In particular, we quantitatively validate the faithfulness of the explanations via the so-called attribution-based confidence metric that is included as a constraint to guide the overall training process in the run-time FL optimization task. In this respect, Integrated-Gradient (IG) as well as Input $\times$ Gradient and SHAP are used to generate the attributions for our proposed in-hoc scheme, wherefore simulation results under different methods confirm its success in tackling the performance-explainability trade-off and its superiority over the unconstrained Integrated-Gradient post-hoc FL baseline.

Post-hoc explanation techniques such as the well-established partial dependence plot (PDP), which investigates feature dependencies, are used in explainable artificial intelligence (XAI) to understand black-box machine learning models. While many real-world applications require dynamic models that constantly adapt over time and react to changes in the underlying distribution, XAI, so far, has primarily considered static learning environments, where models are trained in a batch mode and remain unchanged. We thus propose a novel model-agnostic XAI framework called incremental PDP (iPDP) that extends on the PDP to extract time-dependent feature effects in non-stationary learning environments. We formally analyze iPDP and show that it approximates a time-dependent variant of the PDP that properly reacts to real and virtual concept drift. The time-sensitivity of iPDP is controlled by a single smoothing parameter, which directly corresponds to the variance and the approximation error of iPDP in a static learning environment. We illustrate the efficacy of iPDP by showcasing an example application for drift detection and conducting multiple experiments on real-world and synthetic data sets and streams.

In the field of Explainable Artificial Intelligence (XAI), counterfactual examples explain to a user the predictions of a trained decision model by indicating the modifications to be made to the instance so as to change its associated prediction. These counterfactual examples are generally defined as solutions to an optimization problem whose cost function combines several criteria that quantify desiderata for a good explanation meeting user needs. A large variety of such appropriate properties can be considered, as the user needs are generally unknown and differ from one user to another; their selection and formalization is difficult. To circumvent this issue, several approaches propose to generate, rather than a single one, a set of diverse counterfactual examples to explain a prediction. This paper proposes a review of the numerous, sometimes conflicting, definitions that have been proposed for this notion of diversity. It discusses their underlying principles as well as the hypotheses on the user needs they rely on and proposes to categorize them along several dimensions (explicit vs implicit, universe in which they are defined, level at which they apply), leading to the identification of further research challenges on this topic.