Research Papers

Case-based reasoning networks are machine-learning models that make predictions based on similarity between the input and prototypical parts of training samples, called prototypes. Such models are able to explain each decision by pointing to the prototypes that contributed the most to the final outcome. As the explanation is a core part of the prediction, they are often qualified as ``interpretable by design". While promising, we show that such explanations are sometimes misleading, which hampers their usefulness in safety-critical contexts. In particular, several instances may lead to different predictions and yet have the same explanation. Drawing inspiration from the field of formal eXplainable AI (FXAI), we propose Abductive Latent Explanations (ALEs), a formalism to express sufficient conditions on the intermediate (latent) representation of the instance that imply the prediction. Our approach combines the inherent interpretability of case-based reasoning models and the guarantees provided by formal XAI. We propose a solver-free and scalable algorithm for generating ALEs based on three distinct paradigms, compare them, and present the feasibility of our approach on diverse datasets for both standard and fine-grained image classification. The associated code can be found at https://github.com/julsoria/ale

Survival analysis is critical for cancer prognosis and treatment planning, yet existing methods lack the transparency essential for clinical adoption. While recent pathology agents have demonstrated explainability in diagnostic tasks, they face three limitations for survival prediction: inability to integrate multimodal data, ineffective region-of-interest exploration, and failure to leverage experiential learning from historical cases. We introduce SurvAgent, the first hierarchical chain-of-thought (CoT)-enhanced multi-agent system for multimodal survival prediction. SurvAgent consists of two stages: (1) WSI-Gene CoT-Enhanced Case Bank Construction employs hierarchical analysis through Low-Magnification Screening, Cross-Modal Similarity-Aware Patch Mining, and Confidence-Aware Patch Mining for pathology images, while Gene-Stratified analysis processes six functional gene categories. Both generate structured reports with CoT reasoning, storing complete analytical processes for experiential learning. (2) Dichotomy-Based Multi-Expert Agent Inference retrieves similar cases via RAG and integrates multimodal reports with expert predictions through progressive interval refinement. Extensive experiments on five TCGA cohorts demonstrate SurvAgent's superority over conventional methods, proprietary MLLMs, and medical agents, establishing a new paradigm for explainable AI-driven survival prediction in precision oncology.

Towards Human-AI Synergy in Requirements Engineering: A Framework and Preliminary Study

Mateen Ahmed Abbasi, Petri Ihantola, Tommi Mikkonen +1

The future of Requirements Engineering (RE) is increasingly driven by artificial intelligence (AI), reshaping how we elicit, analyze, and validate requirements. Traditional RE is based on labor-intensive manual processes prone to errors and complexity. AI-powered approaches, specifically large language models (LLMs), natural language processing (NLP), and generative AI, offer transformative solutions and reduce inefficiencies. However, the use of AI in RE also brings challenges like algorithmic bias, lack of explainability, and ethical concerns related to automation. To address these issues, this study introduces the Human-AI RE Synergy Model (HARE-SM), a conceptual framework that integrates AI-driven analysis with human oversight to improve requirements elicitation, analysis, and validation. The model emphasizes ethical AI use through transparency, explainability, and bias mitigation. We outline a multi-phase research methodology focused on preparing RE datasets, fine-tuning AI models, and designing collaborative human-AI workflows. This preliminary study presents the conceptual framework and early-stage prototype implementation, establishing a research agenda and practical design direction for applying intelligent data science techniques to semi-structured and unstructured RE data in collaborative environments.

AI-assisted gait analysis holds promise for improving Parkinson's Disease (PD) care, but current clinical dashboards lack transparency and offer no meaningful way for clinicians to interrogate or contest AI decisions. To address this issue, we present Motion2Meaning, a clinician-centered framework that advances Contestable AI through a tightly integrated interface designed for interpretability, oversight, and procedural recourse. Our approach leverages vertical Ground Reaction Force (vGRF) time-series data from wearable sensors as an objective biomarker of PD motor states. The system comprises three key components: a Gait Data Visualization Interface (GDVI), a one-dimensional Convolutional Neural Network (1D-CNN) that predicts Hoehn & Yahr severity stages, and a Contestable Interpretation Interface (CII) that combines our novel Cross-Modal Explanation Discrepancy (XMED) safeguard with a contestable Large Language Model (LLM). Our 1D-CNN achieves 89.0% F1-score on the public PhysioNet gait dataset. XMED successfully identifies model unreliability by detecting a five-fold increase in explanation discrepancies in incorrect predictions (7.45%) compared to correct ones (1.56%), while our LLM-powered interface enables clinicians to validate correct predictions and successfully contest a portion of the model's errors. A human-centered evaluation of this contestable interface reveals a crucial trade-off between the LLM's factual grounding and its readability and responsiveness to clinical feedback. This work demonstrates the feasibility of combining wearable sensor analysis with Explainable AI (XAI) and contestable LLMs to create a transparent, auditable system for PD gait interpretation that maintains clinical oversight while leveraging advanced AI capabilities. Our implementation is publicly available at: https://github.com/hungdothanh/motion2meaning.

The transition of next generation advanced nuclear reactor systems from analog to fully digital instrumentation and control will necessitate robust mechanisms to safeguard against potential data integrity threats. One challenge is the real-time characterization of false data injections, which can mask sensor signals and potentially disrupt reactor control systems. While significant progress has been made in anomaly detection within reactor systems, potential false data injections have been shown to bypass conventional linear time-invariant state estimators and failure detectors based on statistical thresholds. The dynamic, nonlinear, multi-variate nature of sensor signals, combined with inherent noise and limited availability of real-world training data, makes the characterization of such threats and more importantly their differentiation from anticipated process anomalies particularly challenging. In this paper, we present an eXplainable AI (XAI) framework for identifying non-stationary concurrent replay attacks in nuclear reactor signals with minimal training data. The proposed framework leverages progress on recurrent neural networks and residual analysis coupled with a modified SHAP algorithm and rule-based correlations. The recurrent neural networks are trained only on normal operational data while for residual analysis we introduce an adaptive windowing technique to improve detection accuracy. We successfully benchmarked this framework on a real-world dataset from Purdue's nuclear reactor (PUR-1). We were able to detect false data injections with accuracy higher than 0.93 and less than 0.01 false positives, differentiate from expected process anomalies, and to identify the origin of the falsified signals.

Early detection of lung cancer is critical to improving survival outcomes. We present a deep learning framework for automated lung cancer screening from chest computed tomography (CT) images with integrated explainability. Using the IQ-OTH/NCCD dataset (1,197 scans across Normal, Benign, and Malignant classes), we evaluate a custom convolutional neural network (CNN) and three fine-tuned transfer learning backbones: DenseNet121, ResNet152, and VGG19. Models are trained with cost-sensitive learning to mitigate class imbalance and evaluated via accuracy, precision, recall, F1-score, and ROC-AUC. While ResNet152 achieved the highest accuracy (97.3%), DenseNet121 provided the best overall balance in precision, recall, and F1 (up to 92%, 90%, 91%, respectively). We further apply Shapley Additive Explanations (SHAP) to visualize evidence contributing to predictions, improving clinical transparency. Results indicate that CNN-based approaches augmented with explainability can provide fast, accurate, and interpretable support for lung cancer screening, particularly in resource-limited settings.

Explainable AI (XAI) in creative contexts can go beyond transparency to support artistic engagement, modifiability, and sustained practice. While curated datasets and training human-scale models can offer artists greater agency and control, large-scale generative models like text-to-image diffusion systems often obscure these possibilities. We suggest that even large models can be treated as creative materials if their internal structure is exposed and manipulable. We propose a craft-based approach to explainability rooted in long-term, hands-on engagement akin to Schön's "reflection-in-action" and demonstrate its application through a model-bending and inspection plugin integrated into the node-based interface of ComfyUI. We demonstrate that by interactively manipulating different parts of a generative model, artists can develop an intuition about how each component influences the output.

Multimodal learning has witnessed remarkable advancements in recent years, particularly with the integration of attention-based models, leading to significant performance gains across a variety of tasks. Parallel to this progress, the demand for explainable artificial intelligence (XAI) has spurred a growing body of research aimed at interpreting the complex decision-making processes of these models. This systematic literature review analyzes research published between January 2020 and early 2024 that focuses on the explainability of multimodal models. Framed within the broader goals of XAI, we examine the literature across multiple dimensions, including model architecture, modalities involved, explanation algorithms and evaluation methodologies. Our analysis reveals that most studies are concentrated on vision-language and language-only models, with attention-based techniques being the most commonly employed for explanation. However, these methods often fall short in capturing the full spectrum of interactions between modalities, a challenge further compounded by the architectural heterogeneity across domains. Importantly, we find that evaluation methods for XAI in multimodal settings are largely non-systematic, lacking consistency, robustness, and consideration for modality-specific cognitive and contextual factors. To address these gaps, we not only synthesize findings from the surveyed works but also incorporate a complementary analysis that integrates recent and emerging advances driving multimodal explainability. Based on these insights, we provide a comprehensive set of recommendations aimed at promoting rigorous, transparent, and standardized evaluation and reporting practices in multimodal XAI research. Our goal is to support future research in more interpretable, accountable, and responsible multimodal AI systems, with explainability at their core.

Effective human-AI teaming heavily depends on swift trust, particularly in high-stakes scenarios such as emergency response, where timely and accurate decision-making is critical. In these time-sensitive and cognitively demanding settings, adaptive explainability is essential for fostering trust between human operators and AI systems. However, existing explainable AI (XAI) approaches typically offer uniform explanations and rely heavily on explicit feedback mechanisms, which are often impractical in such high-pressure scenarios. To address this gap, we propose a conceptual framework for adaptive XAI that operates non-intrusively by responding to users' real-time cognitive and emotional states through implicit feedback, thereby enhancing swift trust in high-stakes environments. The proposed adaptive explainability trust framework (AXTF) leverages physiological and behavioral signals, such as EEG, ECG, and eye tracking, to infer user states and support explanation adaptation. At its core is a multi-objective, personalized trust estimation model that maps workload, stress, and emotion to dynamic trust estimates. These estimates guide the modulation of explanation features enabling responsive and personalized support that promotes swift trust in human-AI collaboration. This conceptual framework establishes a foundation for developing adaptive, non-intrusive XAI systems tailored to the rigorous demands of high-pressure, time-sensitive environments.

Understanding the sources of variability in annotations is crucial for developing fair NLP systems, especially for tasks like sexism detection where demographic bias is a concern. This study investigates the extent to which annotator demographic features influence labeling decisions compared to text content. Using a Generalized Linear Mixed Model, we quantify this inf luence, finding that while statistically present, demographic factors account for a minor fraction ( 8%) of the observed variance, with tweet content being the dominant factor. We then assess the reliability of Generative AI (GenAI) models as annotators, specifically evaluating if guiding them with demographic personas improves alignment with human judgments. Our results indicate that simplistic persona prompting often fails to enhance, and sometimes degrades, performance compared to baseline models. Furthermore, explainable AI (XAI) techniques reveal that model predictions rely heavily on content-specific tokens related to sexism, rather than correlates of demographic characteristics. We argue that focusing on content-driven explanations and robust annotation protocols offers a more reliable path towards fairness than potentially persona simulation.

Artificial Intelligence (AI) tools for automating design artifact generation are increasingly used in Requirements Engineering (RE) to transform textual requirements into structured diagrams and models. While these AI tools, particularly those based on Natural Language Processing (NLP), promise to improve efficiency, their adoption remains limited in regulated industries where transparency and traceability are essential. In this paper, we investigate the explainability gap in AI-driven design artifact generation through semi-structured interviews with ten practitioners from safety-critical industries. We examine how current AI-based tools are integrated into workflows and the challenges arising from their lack of explainability. We also explore mitigation strategies, their impact on project outcomes, and features needed to improve usability. Our findings reveal that non-explainable AI outputs necessitate extensive manual validation, reduce stakeholder trust, struggle to handle domain-specific terminology, disrupt team collaboration, and introduce regulatory compliance risks, often negating the anticipated efficiency benefits. To address these issues, we identify key improvements, including source tracing, providing clear justifications for tool-generated decisions, supporting domain-specific adaptation, and enabling compliance validation. This study outlines a practical roadmap for improving the transparency, reliability, and applicability of AI tools in requirements engineering workflows, particularly in regulated and safety-critical environments where explainability is crucial for adoption and certification.

Compressing Deep Neural Networks Using Explainable AI

Kimia Soroush, Mohsen Raji, Behnam Ghavami

Deep neural networks (DNNs) have demonstrated remarkable performance in many tasks but it often comes at a high computational cost and memory usage. Compression techniques, such as pruning and quantization, are applied to reduce the memory footprint of DNNs and make it possible to accommodate them on resource-constrained edge devices. Recently, explainable artificial intelligence (XAI) methods have been introduced with the purpose of understanding and explaining AI methods. XAI can be utilized to get to know the inner functioning of DNNs, such as the importance of different neurons and features in the overall performance of DNNs. In this paper, a novel DNN compression approach using XAI is proposed to efficiently reduce the DNN model size with negligible accuracy loss. In the proposed approach, the importance score of DNN parameters (i.e. weights) are computed using a gradient-based XAI technique called Layer-wise Relevance Propagation (LRP). Then, the scores are used to compress the DNN as follows: 1) the parameters with the negative or zero importance scores are pruned and removed from the model, 2) mixed-precision quantization is applied to quantize the weights with higher/lower score with higher/lower number of bits. The experimental results show that, the proposed compression approach reduces the model size by 64% while the accuracy is improved by 42% compared to the state-of-the-art XAI-based compression method.