Research Papers

In the field of functional genomics, the analysis of gene expression profiles through Machine and Deep Learning is increasingly providing meaningful insight into a number of diseases. The paper proposes a novel algorithm to perform Feature Selection on genomic-scale data, which exploits the reconstruction capabilities of autoencoders and an ad-hoc defined Explainable Artificial Intelligence-based score in order to select the most informative genes for diagnosis, prognosis, and precision medicine. Results of the application on a Chronic Lymphocytic Leukemia dataset evidence the effectiveness of the algorithm, by identifying and suggesting a set of meaningful genes for further medical investigation.

Deep Learning (DL) is one of the most popular research topics in machine learning and DL-driven image recognition systems have developed rapidly. Recent research has employed metamorphic testing (MT) to detect misclassified images. Most of them discuss metamorphic relations (MR), with limited attention given to which regions should be transformed. We focus on the fact that there are sensitive regions where even small transformations can easily change the prediction results and propose an MT framework that efficiently tests for regions prone to misclassification by transforming these sensitive regions. Our evaluation demonstrated that the sensitive regions can be specified by Explainable AI (XAI) and our framework effectively detects faults.

Problems broadly known as algorithmic bias frequently occur in the context of complex socio-technical systems (STS), where observed biases may not be directly attributable to a single automated decision algorithm. As a first investigation of fairness in STS, we focus on the case of Wikipedia. We systematically review 75 papers describing different types of bias in Wikipedia, which we classify and relate to established notions of harm from algorithmic fairness research. By analysing causal relationships between the observed phenomena, we demonstrate the complexity of the socio-technical processes causing harm. Finally, we identify the normative expectations of fairness associated with the different problems and discuss the applicability of existing criteria proposed for machine learning-driven decision systems.

The applications of Artificial Intelligence (AI) methods especially machine learning techniques have increased in recent years. Classification algorithms have been successfully applied to different problems such as requirement classification. Although these algorithms have good performance, most of them cannot explain how they make a decision. Explainable Artificial Intelligence (XAI) is a set of new techniques that explain the predictions of machine learning algorithms. In this work, the applicability of XAI for software requirement classification is studied. An explainable software requirement classifier is presented using the LIME algorithm. The explainability of the proposed method is studied by applying it to the PROMISE software requirement dataset. The results show that XAI can help the analyst or requirement specifier to better understand why a specific requirement is classified as functional or non-functional. The important keywords for such decisions are identified and analyzed in detail. The experimental study shows that the XAI can be used to help analysts and requirement specifiers to better understand the predictions of the classifiers for categorizing software requirements. Also, the effect of the XAI on feature reduction is analyzed. The results showed that the XAI model has a positive role in feature analysis.

The recent release of ChatGPT has gained huge attention and discussion worldwide, with responsible AI being a key topic of discussion. How can we ensure that AI systems, including ChatGPT, are developed and adopted in a responsible way? To tackle the responsible AI challenges, various ethical principles have been released by governments, organisations, and companies. However, those principles are very abstract and not practical enough. Further, significant efforts have been put on algorithm-level solutions that only address a narrow set of principles, such as fairness and privacy. To fill the gap, we adopt a pattern-oriented responsible AI engineering approach and build a Responsible AI Pattern Catalogue to operationalise responsible AI from a system perspective. In this article, we first summarise the major challenges in operationalising responsible AI at scale and introduce how we use the Responsible AI Pattern Catalogue to address those challenges. We then examine the risks at each stage of the chatbot development process and recommend pattern-driven mitigations to evaluate the the usefulness of the Responsible AI Pattern Catalogue in a real-world setting.

The use of deep learning in computer vision tasks such as image classification has led to a rapid increase in the performance of such systems. Due to this substantial increment in the utility of these systems, the use of artificial intelligence in many critical tasks has exploded. In the medical domain, medical image classification systems are being adopted due to their high accuracy and near parity with human physicians in many tasks. However, these artificial intelligence systems are extremely complex and are considered black boxes by scientists, due to the difficulty in interpreting what exactly led to the predictions made by these models. When these systems are being used to assist high-stakes decision-making, it is extremely important to be able to understand, verify and justify the conclusions reached by the model. The research techniques being used to gain insight into the black-box models are in the field of explainable artificial intelligence (XAI). In this paper, we evaluated three different XAI methods across two convolutional neural network models trained to classify lung cancer from histopathological images. We visualized the outputs and analyzed the performance of these methods, in order to better understand how to apply explainable artificial intelligence in the medical domain.

SCALES: From Fairness Principles to Constrained Decision-Making

Sreejith Balakrishnan, Jianxin Bi, Harold Soh

This paper proposes SCALES, a general framework that translates well-established fairness principles into a common representation based on the Constraint Markov Decision Process (CMDP). With the help of causal language, our framework can place constraints on both the procedure of decision making (procedural fairness) as well as the outcomes resulting from decisions (outcome fairness). Specifically, we show that well-known fairness principles can be encoded either as a utility component, a non-causal component, or a causal component in a SCALES-CMDP. We illustrate SCALES using a set of case studies involving a simulated healthcare scenario and the real-world COMPAS dataset. Experiments demonstrate that our framework produces fair policies that embody alternative fairness principles in single-step and sequential decision-making scenarios.

Seeking Interpretability and Explainability in Binary Activated Neural Networks

Benjamin Leblanc, Pascal Germain

We study the use of binary activated neural networks as interpretable and explainable predictors in the context of regression tasks on tabular data; more specifically, we provide guarantees on their expressiveness, present an approach based on the efficient computation of SHAP values for quantifying the relative importance of the features, hidden neurons and even weights. As the model's simplicity is instrumental in achieving interpretability, we propose a greedy algorithm for building compact binary activated networks. This approach doesn't need to fix an architecture for the network in advance: it is built one layer at a time, one neuron at a time, leading to predictors that aren't needlessly complex for a given task.

Today's large-scale algorithmic and automated deployment of decision-making systems threatens to exclude marginalized communities. Thus, the emergent danger comes from the effectiveness and the propensity of such systems to replicate, reinforce, or amplify harmful existing discriminatory acts. Algorithmic bias exposes a deeply entrenched encoding of a range of unwanted biases that can have profound real-world effects that manifest in domains from employment, to housing, to healthcare. The last decade of research and examples on these effects further underscores the need to examine any claim of a value-neutral technology. This work examines the intersection of algorithmic bias in consumer mobile health technologies (mHealth). We include mHealth, a term used to describe mobile technology and associated sensors to provide healthcare solutions through patient journeys. We also include mental and behavioral health (mental and physiological) as part of our study. Furthermore, we explore to what extent current mechanisms - legal, technical, and or normative - help mitigate potential risks associated with unwanted bias in intelligent systems that make up the mHealth domain. We provide additional guidance on the role and responsibilities technologists and policymakers have to ensure that such systems empower patients equitably.

Using Sentence Embeddings and Semantic Similarity for Seeking Consensus when Assessing Trustworthy AI

Dennis Vetter, Jesmin Jahan Tithi, Magnus Westerlund +2

Assessing the trustworthiness of artificial intelligence systems requires knowledge from many different disciplines. These disciplines do not necessarily share concepts between them and might use words with different meanings, or even use the same words differently. Additionally, experts from different disciplines might not be aware of specialized terms readily used in other disciplines. Therefore, a core challenge of the assessment process is to identify when experts from different disciplines talk about the same problem but use different terminologies. In other words, the problem is to group problem descriptions (a.k.a. issues) with the same semantic meaning but described using slightly different terminologies. In this work, we show how we employed recent advances in natural language processing, namely sentence embeddings and semantic textual similarity, to support this identification process and to bridge communication gaps in interdisciplinary teams of experts assessing the trustworthiness of an artificial intelligence system used in healthcare.

Artificial Intelligence (AI) as a highly transformative technology take on a special role as both an enabler and a threat to UN Sustainable Development Goals (SDGs). AI Ethics and emerging high-level policy efforts stand at the pivot point between these outcomes but is barred from effect due the abstraction gap between high-level values and responsible action. In this paper the Responsible Norms (RAIN) framework is presented, bridging this gap thereby enabling effective high-level control of AI impact. With effective and operationalized AI Ethics, AI technologies can be directed towards global sustainable development.

Existing methods of explainable AI and interpretable ML cannot explain change in the values of an output variable for a statistical unit in terms of the change in the input values and the change in the "mechanism" (the function transforming input to output). We propose two methods based on counterfactuals for explaining unit-level changes at various input granularities using the concept of Shapley values from game theory. These methods satisfy two key axioms desirable for any unit-level change attribution method. Through simulations, we study the reliability and the scalability of the proposed methods. We get sensible results from a case study on identifying the drivers of the change in the earnings for individuals in the US.