Research Papers

A significant body of recent research in the field of Learning Analytics has focused on leveraging machine learning approaches for predicting at-risk students in order to initiate timely interventions and thereby elevate retention and completion rates. The overarching feature of the majority of these research studies has been on the science of prediction only. The component of predictive analytics concerned with interpreting the internals of the models and explaining their predictions for individual cases to stakeholders has largely been neglected. Additionally, works that attempt to employ data-driven prescriptive analytics to automatically generate evidence-based remedial advice for at-risk learners are in their infancy. eXplainable AI is a field that has recently emerged providing cutting-edge tools which support transparent predictive analytics and techniques for generating tailored advice for at-risk students. This study proposes a novel framework that unifies both transparent machine learning as well as techniques for enabling prescriptive analytics, while integrating the latest advances in large language models. This work practically demonstrates the proposed framework using predictive models for identifying at-risk learners of programme non-completion. The study then further demonstrates how predictive modelling can be augmented with prescriptive analytics on two case studies in order to generate human-readable prescriptive feedback for those who are at risk using ChatGPT.

Towards the Augmented Pathologist: Challenges of Explainable-AI in Digital Pathology

Andreas Holzinger, Bernd Malle, Peter Kieseberg +4

Digital pathology is not only one of the most promising fields of diagnostic medicine, but at the same time a hot topic for fundamental research. Digital pathology is not just the transfer of histopathological slides into digital representations. The combination of different data sources (images, patient records, and *omics data) together with current advances in artificial intelligence/machine learning enable to make novel information accessible and quantifiable to a human expert, which is not yet available and not exploited in current medical settings. The grand goal is to reach a level of usable intelligence to understand the data in the context of an application task, thereby making machine decisions transparent, interpretable and explainable. The foundation of such an "augmented pathologist" needs an integrated approach: While machine learning algorithms require many thousands of training examples, a human expert is often confronted with only a few data points. Interestingly, humans can learn from such few examples and are able to instantly interpret complex patterns. Consequently, the grand goal is to combine the possibilities of artificial intelligence with human intelligence and to find a well-suited balance between them to enable what neither of them could do on their own. This can raise the quality of education, diagnosis, prognosis and prediction of cancer and other diseases. In this paper we describe some (incomplete) research issues which we believe should be addressed in an integrated and concerted effort for paving the way towards the augmented pathologist.

Explainable AI (XAI) refers to techniques that provide human-understandable insights into the workings of AI models. Recently, the focus of XAI is being extended toward explaining Large Language Models (LLMs). This extension calls for a significant transformation in the XAI methodologies for two reasons. First, many existing XAI methods cannot be directly applied to LLMs due to their complexity and advanced capabilities. Second, as LLMs are increasingly deployed in diverse applications, the role of XAI shifts from merely opening the ``black box'' to actively enhancing the productivity and applicability of LLMs in real-world settings. Meanwhile, the conversation and generation abilities of LLMs can reciprocally enhance XAI. Therefore, in this paper, we introduce Usable XAI in the context of LLMs by analyzing (1) how XAI can explain and improve LLM-based AI systems and (2) how XAI techniques can be improved by using LLMs. We introduce 10 strategies, introducing the key techniques for each and discussing their associated challenges. We also provide case studies to demonstrate how to obtain and leverage explanations. The code used in this paper can be found at: https://github.com/JacksonWuxs/UsableXAI_LLM.

We describe an explainable AI saliency map method for use with deep convolutional neural networks (CNN) that is much more efficient than popular fine-resolution gradient methods. It is also quantitatively similar or better in accuracy. Our technique works by measuring information at the end of each network scale which is then combined into a single saliency map. We describe how saliency measures can be made more efficient by exploiting Saliency Map Order Equivalence. We visualize individual scale/layer contributions by using a Layer Ordered Visualization of Information. This provides an interesting comparison of scale information contributions within the network not provided by other saliency map methods. Using our method instead of Guided Backprop, coarse-resolution class activation methods such as Grad-CAM and Grad-CAM++ seem to yield demonstrably superior results without sacrificing speed. This will make fine-resolution saliency methods feasible on resource limited platforms such as robots, cell phones, low-cost industrial devices, astronomy and satellite imagery.

LLMs Encode Harmfulness and Refusal Separately

Jiachen Zhao, Jing Huang, Zhengxuan Wu +2

LLMs are trained to refuse harmful instructions, but do they truly understand harmfulness beyond just refusing? Prior work has shown that LLMs' refusal behaviors can be mediated by a one-dimensional subspace, i.e., a refusal direction. In this work, we identify a new dimension to analyze safety mechanisms in LLMs, i.e., harmfulness, which is encoded internally as a separate concept from refusal. There exists a harmfulness direction that is distinct from the refusal direction. As causal evidence, steering along the harmfulness direction can lead LLMs to interpret harmless instructions as harmful, but steering along the refusal direction tends to elicit refusal responses directly without reversing the model's judgment on harmfulness. Furthermore, using our identified harmfulness concept, we find that certain jailbreak methods work by reducing the refusal signals without reversing the model's internal belief of harmfulness. We also find that adversarially finetuning models to accept harmful instructions has minimal impact on the model's internal belief of harmfulness. These insights lead to a practical safety application: The model's latent harmfulness representation can serve as an intrinsic safeguard (Latent Guard) for detecting unsafe inputs and reducing over-refusals that is robust to finetuning attacks. For instance, our Latent Guard achieves performance comparable to or better than Llama Guard 3 8B, a dedicated finetuned safeguard model, across different jailbreak methods. Our findings suggest that LLMs' internal understanding of harmfulness is more robust than their refusal decision to diverse input instructions, offering a new perspective to study AI safety.

Recent work discovered Emergent Misalignment (EM): fine-tuning large language models on narrowly harmful datasets can lead them to become broadly misaligned. A survey of experts prior to publication revealed this was highly unexpected, demonstrating critical gaps in our understanding of model alignment. In this work, we both advance understanding and provide tools for future research. Using new narrowly misaligned datasets, we create a set of improved model organisms that achieve 99% coherence (vs. 67% prior), work with smaller 0.5B parameter models (vs. 32B), and that induce misalignment using a single rank-1 LoRA adapter. We demonstrate that EM occurs robustly across diverse model sizes, three model families, and numerous training protocols including full supervised fine-tuning. Leveraging these cleaner model organisms, we isolate a mechanistic phase transition and demonstrate that it corresponds to a robust behavioural phase transition in all studied organisms. Aligning large language models is critical for frontier AI safety, yet EM exposes how far we are from achieving this robustly. By distilling clean model organisms that isolate a minimal alignment-compromising change, and where this is learnt, we establish a foundation for future research into understanding and mitigating alignment risks in LLMs.

Breast cancer has rapidly increased in prevalence in recent years, making it one of the leading causes of mortality worldwide. Among all cancers, it is by far the most common. Diagnosing this illness manually requires significant time and expertise. Since detecting breast cancer is a time-consuming process, preventing its further spread can be aided by creating machine-based forecasts. Machine learning and Explainable AI are crucial in classification as they not only provide accurate predictions but also offer insights into how the model arrives at its decisions, aiding in the understanding and trustworthiness of the classification results. In this study, we evaluate and compare the classification accuracy, precision, recall, and F-1 scores of five different machine learning methods using a primary dataset (500 patients from Dhaka Medical College Hospital). Five different supervised machine learning techniques, including decision tree, random forest, logistic regression, naive bayes, and XGBoost, have been used to achieve optimal results on our dataset. Additionally, this study applied SHAP analysis to the XGBoost model to interpret the model's predictions and understand the impact of each feature on the model's output. We compared the accuracy with which several algorithms classified the data, as well as contrasted with other literature in this field. After final evaluation, this study found that XGBoost achieved the best model accuracy, which is 97%.

Research in artificial intelligence (AI)-assisted decision-making is experiencing tremendous growth with a constantly rising number of studies evaluating the effect of AI with and without techniques from the field of explainable AI (XAI) on human decision-making performance. However, as tasks and experimental setups vary due to different objectives, some studies report improved user decision-making performance through XAI, while others report only negligible effects. Therefore, in this article, we present an initial synthesis of existing research on XAI studies using a statistical meta-analysis to derive implications across existing research. We observe a statistically positive impact of XAI on users' performance. Additionally, the first results indicate that human-AI decision-making tends to yield better task performance on text data. However, we find no effect of explanations on users' performance compared to sole AI predictions. Our initial synthesis gives rise to future research investigating the underlying causes and contributes to further developing algorithms that effectively benefit human decision-makers by providing meaningful explanations.

One principal impediment in the successful deployment of AI-based Computer-Aided Diagnosis (CAD) systems in clinical workflows is their lack of transparent decision making. Although commonly used eXplainable AI methods provide some insight into opaque algorithms, such explanations are usually convoluted and not readily comprehensible except by highly trained experts. The explanation of decisions regarding the malignancy of skin lesions from dermoscopic images demands particular clarity, as the underlying medical problem definition is itself ambiguous. This work presents ExAID (Explainable AI for Dermatology), a novel framework for biomedical image analysis, providing multi-modal concept-based explanations consisting of easy-to-understand textual explanations supplemented by visual maps justifying the predictions. ExAID relies on Concept Activation Vectors to map human concepts to those learnt by arbitrary Deep Learning models in latent space, and Concept Localization Maps to highlight concepts in the input space. This identification of relevant concepts is then used to construct fine-grained textual explanations supplemented by concept-wise location information to provide comprehensive and coherent multi-modal explanations. All information is comprehensively presented in a diagnostic interface for use in clinical routines. An educational mode provides dataset-level explanation statistics and tools for data and model exploration to aid medical research and education. Through rigorous quantitative and qualitative evaluation of ExAID, we show the utility of multi-modal explanations for CAD-assisted scenarios even in case of wrong predictions. We believe that ExAID will provide dermatologists an effective screening tool that they both understand and trust. Moreover, it will be the basis for similar applications in other biomedical imaging fields.

We are used to the availability of big data generated in nearly all fields of science as a consequence of technological progress. However, the analysis of such data possess vast challenges. One of these relates to the explainability of artificial intelligence (AI) or machine learning methods. Currently, many of such methods are non-transparent with respect to their working mechanism and for this reason are called black box models, most notably deep learning methods. However, it has been realized that this constitutes severe problems for a number of fields including the health sciences and criminal justice and arguments have been brought forward in favor of an explainable AI. In this paper, we do not assume the usual perspective presenting explainable AI as it should be, but rather we provide a discussion what explainable AI can be. The difference is that we do not present wishful thinking but reality grounded properties in relation to a scientific theory beyond physics.

From Clustering to Cluster Explanations via Neural Networks

Jacob Kauffmann, Malte Esders, Lukas Ruff +3

A recent trend in machine learning has been to enrich learned models with the ability to explain their own predictions. The emerging field of Explainable AI (XAI) has so far mainly focused on supervised learning, in particular, deep neural network classifiers. In many practical problems however, label information is not given and the goal is instead to discover the underlying structure of the data, for example, its clusters. While powerful methods exist for extracting the cluster structure in data, they typically do not answer the question why a certain data point has been assigned to a given cluster. We propose a new framework that can, for the first time, explain cluster assignments in terms of input features in an efficient and reliable manner. It is based on the novel insight that clustering models can be rewritten as neural networks - or 'neuralized'. Cluster predictions of the obtained networks can then be quickly and accurately attributed to the input features. Several showcases demonstrate the ability of our method to assess the quality of learned clusters and to extract novel insights from the analyzed data and representations.

LLMs for Explainable AI: A Comprehensive Survey

Ahsan Bilal, David Ebert, Beiyu Lin

Large Language Models (LLMs) offer a promising approach to enhancing Explainable AI (XAI) by transforming complex machine learning outputs into easy-to-understand narratives, making model predictions more accessible to users, and helping bridge the gap between sophisticated model behavior and human interpretability. AI models, such as state-of-the-art neural networks and deep learning models, are often seen as "black boxes" due to a lack of transparency. As users cannot fully understand how the models reach conclusions, users have difficulty trusting decisions from AI models, which leads to less effective decision-making processes, reduced accountabilities, and unclear potential biases. A challenge arises in developing explainable AI (XAI) models to gain users' trust and provide insights into how models generate their outputs. With the development of Large Language Models, we want to explore the possibilities of using human language-based models, LLMs, for model explainabilities. This survey provides a comprehensive overview of existing approaches regarding LLMs for XAI, and evaluation techniques for LLM-generated explanation, discusses the corresponding challenges and limitations, and examines real-world applications. Finally, we discuss future directions by emphasizing the need for more interpretable, automated, user-centric, and multidisciplinary approaches for XAI via LLMs.