Research Papers

Large language models (LLMs) hold substantial promise for clinical decision support. However, their widespread adoption in medicine, particularly in healthcare, is hindered by their propensity to generate false or misleading outputs, known as hallucinations. In high-stakes domains such as women's health (obstetrics & gynaecology), where errors in clinical reasoning can have profound consequences for maternal and neonatal outcomes, ensuring the reliability of AI-generated responses is critical. Traditional methods for quantifying uncertainty, such as perplexity, fail to capture meaning-level inconsistencies that lead to misinformation. Here, we evaluate semantic entropy (SE), a novel uncertainty metric that assesses meaning-level variation, to detect hallucinations in AI-generated medical content. Using a clinically validated dataset derived from UK RCOG MRCOG examinations, we compared SE with perplexity in identifying uncertain responses. SE demonstrated superior performance, achieving an AUROC of 0.76 (95% CI: 0.75-0.78), compared to 0.62 (0.60-0.65) for perplexity. Clinical expert validation further confirmed its effectiveness, with SE achieving near-perfect uncertainty discrimination (AUROC: 0.97). While semantic clustering was successful in only 30% of cases, SE remains a valuable tool for improving AI safety in women's health. These findings suggest that SE could enable more reliable AI integration into clinical practice, particularly in resource-limited settings where LLMs could augment care. This study highlights the potential of SE as a key safeguard in the responsible deployment of AI-driven tools in women's health, leading to safer and more effective digital health interventions.

The rapid aging of the global population has highlighted the need for technologies to support elderly, particularly in healthcare and emotional well-being. Facial expression recognition (FER) systems offer a non-invasive means of monitoring emotional states, with applications in assisted living, mental health support, and personalized care. This study presents a systematic review of deep learning-based FER systems, focusing on their applications for the elderly population. Following a rigorous methodology, we analyzed 31 studies published over the last decade, addressing challenges such as the scarcity of elderly-specific datasets, class imbalances, and the impact of age-related facial expression differences. Our findings show that convolutional neural networks remain dominant in FER, and especially lightweight versions for resource-constrained environments. However, existing datasets often lack diversity in age representation, and real-world deployment remains limited. Additionally, privacy concerns and the need for explainable artificial intelligence emerged as key barriers to adoption. This review underscores the importance of developing age-inclusive datasets, integrating multimodal solutions, and adopting XAI techniques to enhance system usability, reliability, and trustworthiness. We conclude by offering recommendations for future research to bridge the gap between academic progress and real-world implementation in elderly care.

Responsible Artificial Intelligence (RAI) addresses the ethical and regulatory challenges of deploying AI systems in high-risk scenarios. This paper proposes a comprehensive framework for the design of an RAI system (RAIS) that integrates five key dimensions: domain definition, trustworthy AI design, auditability, accountability, and governance. Unlike prior work that treats these components in isolation, our proposal emphasizes their inter-dependencies and iterative feedback loops, enabling proactive and reactive accountability throughout the AI lifecycle. Beyond presenting the framework, we synthesize recent developments in global AI governance and analyze limitations in existing principles-based approaches, highlighting fragmentation, implementation gaps, and the need for participatory governance. The paper also identifies critical challenges and research directions for the RAIS framework, including sector-specific adaptation and operationalization, to support certification, post-deployment monitoring, and risk-based auditing. By bridging technical design and institutional responsibility, this work offers a practical blueprint for embedding responsibility throughout the AI lifecycle, enabling transparent, ethically aligned, and legally compliant AI-based systems.

Scaffolding Large Language Models (LLMs) into multi-agent systems often improves performance on complex tasks, but the safety impact of such scaffolds has not been thoroughly explored. We introduce AgentBreeder, a framework for multi-objective self-improving evolutionary search over scaffolds. We evaluate discovered scaffolds on widely recognized reasoning, mathematics, and safety benchmarks and compare them with popular baselines. In "blue" mode, we see a 79.4% average uplift in safety benchmark performance while maintaining or improving capability scores. In "red" mode, we find adversarially weak scaffolds emerging concurrently with capability optimization. Our work demonstrates the risks of multi-agent scaffolding and provides a framework for mitigating them. Code is available at https://github.com/jrosseruk/AgentBreeder.

Suicidal ideation detection is crucial for preventing suicides, a leading cause of death worldwide. Many individuals express suicidal thoughts on social media, offering a vital opportunity for early detection through advanced machine learning techniques. The identification of suicidal ideation in social media text is improved by utilising a hybrid framework that integrates Convolutional Neural Networks (CNN) and Bidirectional Long Short-Term Memory (BiLSTM), enhanced with an attention mechanism. To enhance the interpretability of the model's predictions, Explainable AI (XAI) methods are applied, with a particular focus on SHapley Additive exPlanations (SHAP), are incorporated. At first, the model managed to reach an accuracy of 92.81%. By applying fine-tuning and early stopping techniques, the accuracy improved to 94.29%. The SHAP analysis revealed key features influencing the model's predictions, such as terms related to mental health struggles. This level of transparency boosts the model's credibility while helping mental health professionals understand and trust the predictions. This work highlights the potential for improving the accuracy and interpretability of detecting suicidal tendencies, making a valuable contribution to the progress of mental health monitoring systems. It emphasizes the significance of blending powerful machine learning methods with explainability to develop reliable and impactful mental health solutions.

This study examines the expressed ethical logic of eight prominent large language models from OpenAI, Meta, Perplexity, Anthropic, Google, Mistral, DeepSeek, and xAI. Each model answered direct questions about its ethical principles and responded to five classic moral dilemmas. Responses were analyzed using the consequentialist/deontological distinction, Moral Foundations Theory, and Kohlbergs stages of moral development. Across models, ethical judgments were broadly convergent and typically emphasized harm minimization, fairness, and contextual qualification. The models nevertheless differed in their willingness to decide, the rationales used to defend choices, and the relative weight assigned to rules, outcomes, role obligations, and interpersonal considerations. Their self-descriptions were erudite, cautious, and strongly shaped by a conversational persona. The analysis of self-reports has been central to the study of human psychology and communication. We propose, with appropriate cautions, it can enhance our understanding of how artificial intelligence works and how it may be able to augment human ethical behavior

We propose a conceptualization and implementation of AI ethics via the capability approach. We aim to show that conceptualizing AI ethics through the capability approach has two main advantages for AI ethics as a discipline. First, it helps clarify the ethical dimension of AI tools. Second, it provides guidance to implementing ethical considerations within the design of AI tools. We illustrate these advantages in the context of AI tools in medicine, by showing how ethics-based auditing of AI tools in medicine can greatly benefit from our capability-based approach.

Brain cancer represents a major challenge in medical diagnostics, requisite precise and timely detection for effective treatment. Diagnosis initially relies on the proficiency of radiologists, which can cause difficulties and threats when the expertise is sparse. Despite the use of imaging resources, brain cancer remains often difficult, time-consuming, and vulnerable to intraclass variability. This study conveys the Bangladesh Brain Cancer MRI Dataset, containing 6,056 MRI images organized into three categories: Brain Tumor, Brain Glioma, and Brain Menin. The dataset was collected from several hospitals in Bangladesh, providing a diverse and realistic sample for research. We implemented advanced deep learning models, and DenseNet169 achieved exceptional results, with accuracy, precision, recall, and F1-Score all reaching 0.9983. In addition, Explainable AI (XAI) methods including GradCAM, GradCAM++, ScoreCAM, and LayerCAM were employed to provide visual representations of the decision-making processes of the models. In the context of brain cancer, these techniques highlight DenseNet169's potential to enhance diagnostic accuracy while simultaneously offering transparency, facilitating early diagnosis and better patient outcomes.

Chronic Kidney Disease (CKD) represents a significant global health challenge, characterized by the progressive decline in renal function, leading to the accumulation of waste products and disruptions in fluid balance within the body. Given its pervasive impact on public health, there is a pressing need for effective diagnostic tools to enable timely intervention. Our study delves into the application of cutting-edge transfer learning models for the early detection of CKD. Leveraging a comprehensive and publicly available dataset, we meticulously evaluate the performance of several state-of-the-art models, including EfficientNetV2, InceptionNetV2, MobileNetV2, and the Vision Transformer (ViT) technique. Remarkably, our analysis demonstrates superior accuracy rates, surpassing the 90% threshold with MobileNetV2 and achieving 91.5% accuracy with ViT. Moreover, to enhance predictive capabilities further, we integrate these individual methodologies through ensemble modeling, resulting in our ensemble model exhibiting a remarkable 96% accuracy in the early detection of CKD. This significant advancement holds immense promise for improving clinical outcomes and underscores the critical role of machine learning in addressing complex medical challenges.

In the field of autonomous surface vehicles (ASVs), devising decision-making and obstacle avoidance solutions that address maritime COLREGs (Collision Regulations), primarily defined for human operators, has long been a pressing challenge. Recent advancements in explainable Artificial Intelligence (AI) and machine learning have shown promise in enabling human-like decision-making. Notably, significant developments have occurred in the application of Large Language Models (LLMs) to the decision-making of complex systems, such as self-driving cars. The textual and somewhat ambiguous nature of COLREGs (from an algorithmic perspective), however, poses challenges that align well with the capabilities of LLMs, suggesting that LLMs may become increasingly suitable for this application soon. This paper presents and demonstrates the first application of LLM-based decision-making and control for ASVs. The proposed method establishes a high-level decision-maker that uses online collision risk indices and key measurements to make decisions for safe manoeuvres. A tailored design and runtime structure is developed to support training and real-time action generation on a realistic ASV model. Local planning and control algorithms are integrated to execute the commands for waypoint following and collision avoidance at a lower level. To the authors' knowledge, this study represents the first attempt to apply explainable AI to the dynamic control problem of maritime systems recognising the COLREGs rules, opening new avenues for research in this challenging area. Results obtained across multiple test scenarios demonstrate the system's ability to maintain online COLREGs compliance, accurate waypoint tracking, and feasible control, while providing human-interpretable reasoning for each decision.

We introduce PASTA (Perceptual Assessment System for explanaTion of Artificial Intelligence), a novel human-centric framework for evaluating eXplainable AI (XAI) techniques in computer vision. Our first contribution is the creation of the PASTA-dataset, the first large-scale benchmark that spans a diverse set of models and both saliency-based and concept-based explanation methods. This dataset enables robust, comparative analysis of XAI techniques based on human judgment. Our second contribution is an automated, data-driven benchmark that predicts human preferences using the PASTA-dataset. This scoring called PASTA-score method offers scalable, reliable, and consistent evaluation aligned with human perception. Additionally, our benchmark allows for comparisons between explanations across different modalities, an aspect previously unaddressed. We then propose to apply our scoring method to probe the interpretability of existing models and to build more human interpretable XAI methods.

The field of "explainable artificial intelligence" (XAI) seemingly addresses the desire that decisions of machine learning systems should be human-understandable. However, in its current state, XAI itself needs scrutiny. Popular methods cannot reliably answer relevant questions about ML models, their training data, or test inputs, because they systematically attribute importance to input features that are independent of the prediction target. This limits the utility of XAI for diagnosing and correcting data and models, for scientific discovery, and for identifying intervention targets. The fundamental reason for this is that current XAI methods do not address well-defined problems and are not evaluated against targeted criteria of explanation correctness. Researchers should formally define the problems they intend to solve and design methods accordingly. This will lead to diverse use-case-dependent notions of explanation correctness and objective metrics of explanation performance that can be used to validate XAI algorithms.