Research Papers

Deep learning (DL) has substantially enhanced natural language processing (NLP) in healthcare research. However, the increasing complexity of DL-based NLP necessitates transparent model interpretability, or at least explainability, for reliable decision-making. This work presents a thorough scoping review of explainable and interpretable DL in healthcare NLP. The term "eXplainable and Interpretable Artificial Intelligence" (XIAI) is introduced to distinguish XAI from IAI. Different models are further categorized based on their functionality (model-, input-, output-based) and scope (local, global). Our analysis shows that attention mechanisms are the most prevalent emerging IAI technique. The use of IAI is growing, distinguishing it from XAI. The major challenges identified are that most XIAI does not explore "global" modelling processes, the lack of best practices, and the lack of systematic evaluation and benchmarks. One important opportunity is to use attention mechanisms to enhance multi-modal XIAI for personalized medicine. Additionally, combining DL with causal logic holds promise. Our discussion encourages the integration of XIAI in Large Language Models (LLMs) and domain-specific smaller models. In conclusion, XIAI adoption in healthcare requires dedicated in-house expertise. Collaboration with domain experts, end-users, and policymakers can lead to ready-to-use XIAI methods across NLP and medical tasks. While challenges exist, XIAI techniques offer a valuable foundation for interpretable NLP algorithms in healthcare.

For synergistic interactions between humans and artificial intelligence (AI) systems, AI outputs often need to be explainable to people. Explainable AI (XAI) systems are commonly tested in human user studies. However, whether XAI researchers consider potential cultural differences in human explanatory needs remains unexplored. We highlight psychological research that found significant differences in human explanations between many people from Western, commonly individualist countries and people from non-Western, often collectivist countries. We argue that XAI research currently overlooks these variations and that many popular XAI designs implicitly and problematically assume that Western explanatory needs are shared cross-culturally. Additionally, we systematically reviewed over 200 XAI user studies and found that most studies did not consider relevant cultural variations, sampled only Western populations, but drew conclusions about human-XAI interactions more generally. We also analyzed over 30 literature reviews of XAI studies. Most reviews did not mention cultural differences in explanatory needs or flag overly broad cross-cultural extrapolations of XAI user study results. Combined, our analyses provide evidence of a cultural bias toward Western populations in XAI research, highlighting an important knowledge gap regarding how culturally diverse users may respond to widely used XAI systems that future work can and should address.

With the level of automation increases in vehicles, such as conditional and highly automated vehicles (AVs), drivers are becoming increasingly out of the control loop, especially in unexpected driving scenarios. Although it might be not necessary to require the drivers to intervene on most occasions, it is still important to improve drivers' situation awareness (SA) in unexpected driving scenarios to improve their trust in and acceptance of AVs. In this study, we conceptualized SA at the levels of perception (SA L1), comprehension (SA L2), and projection (SA L3), and proposed an SA level-based explanation framework based on explainable AI. Then, we examined the effects of these explanations and their modalities on drivers' situational trust, cognitive workload, as well as explanation satisfaction. A three (SA levels: SA L1, SA L2 and SA L3) by two (explanation modalities: visual, visual + audio) between-subjects experiment was conducted with 340 participants recruited from Amazon Mechanical Turk. The results indicated that by designing the explanations using the proposed SA-based framework, participants could redirect their attention to the important objects in the traffic and understand their meaning for the AV system. This improved their SA and filled the gap of understanding the correspondence of AV's behavior in the particular situations which also increased their situational trust in AV. The results showed that participants reported the highest trust with SA L2 explanations, although the mental workload was assessed higher in this level. The results also provided insights into the relationship between the amount of information in explanations and modalities, showing that participants were more satisfied with visual-only explanations in the SA L1 and SA L2 conditions and were more satisfied with visual and auditory explanations in the SA L3 condition.

Current models on Explainable Artificial Intelligence (XAI) have shown an evident and quantified lack of reliability for measuring feature-relevance when statistically entangled features are proposed for training deep classifiers. There has been an increase in the application of Deep Learning in clinical trials to predict early diagnosis of neuro-developmental disorders, such as Autism Spectrum Disorder (ASD). However, the inclusion of more reliable saliency-maps to obtain more trustworthy and interpretable metrics using neural activity features is still insufficiently mature for practical applications in diagnostics or clinical trials. Moreover, in ASD research the inclusion of deep classifiers that use neural measures to predict viewed facial emotions is relatively unexplored. Therefore, in this study we propose the evaluation of a Convolutional Neural Network (CNN) for electroencephalography (EEG)-based facial emotion recognition decoding complemented with a novel RemOve-And-Retrain (ROAR) methodology to recover highly relevant features used in the classifier. Specifically, we compare well-known relevance maps such as Layer-Wise Relevance Propagation (LRP), PatternNet, Pattern-Attribution, and Smooth-Grad Squared. This study is the first to consolidate a more transparent feature-relevance calculation for a successful EEG-based facial emotion recognition using a within-subject-trained CNN in typically-developed and ASD individuals.

Rapid development of artificial intelligence (AI) systems amplify many concerns in society. These AI algorithms inherit different biases from humans due to mysterious operational flow and because of that it is becoming adverse in usage. As a result, researchers have started to address the issue by investigating deeper in the direction towards Responsible and Explainable AI. Among variety of applications of AI, facial expression recognition might not be the most important one, yet is considered as a valuable part of human-AI interaction. Evolution of facial expression recognition from the feature based methods to deep learning drastically improve quality of such algorithms. This research work aims to study a gender bias in deep learning methods for facial expression recognition by investigating six distinct neural networks, training them, and further analysed on the presence of bias, according to the three definition of fairness. The main outcomes show which models are gender biased, which are not and how gender of subject affects its emotion recognition. More biased neural networks show bigger accuracy gap in emotion recognition between male and female test sets. Furthermore, this trend keeps for true positive and false positive rates. In addition, due to the nature of the research, we can observe which types of emotions are better classified for men and which for women. Since the topic of biases in facial expression recognition is not well studied, a spectrum of continuation of this research is truly extensive, and may comprise detail analysis of state-of-the-art methods, as well as targeting other biases.

Artificial intelligence (AI) has shown great promise for diagnostic imaging assessments. However, the application of AI to support medical diagnostics in clinical routine comes with many challenges. The algorithms should have high prediction accuracy but also be transparent, understandable and reliable. Thus, explainable artificial intelligence (XAI) is highly relevant for this domain. We present a survey on XAI within digital pathology, a medical imaging sub-discipline with particular characteristics and needs. The review includes several contributions. Firstly, we give a thorough overview of current XAI techniques of potential relevance for deep learning methods in pathology imaging, and categorise them from three different aspects. In doing so, we incorporate uncertainty estimation methods as an integral part of the XAI landscape. We also connect the technical methods to the specific prerequisites in digital pathology and present findings to guide future research efforts. The survey is intended for both technical researchers and medical professionals, one of the objectives being to establish a common ground for cross-disciplinary discussions.

Despite the popularity of explainable AI, there is limited work on effective methods for unsupervised learning. We study algorithms for $k$-means clustering, focusing on a trade-off between explainability and accuracy. Following prior work, we use a small decision tree to partition a dataset into $k$ clusters. This enables us to explain each cluster assignment by a short sequence of single-feature thresholds. While larger trees produce more accurate clusterings, they also require more complex explanations. To allow flexibility, we develop a new explainable $k$-means clustering algorithm, ExKMC, that takes an additional parameter $k' \geq k$ and outputs a decision tree with $k'$ leaves. We use a new surrogate cost to efficiently expand the tree and to label the leaves with one of $k$ clusters. We prove that as $k'$ increases, the surrogate cost is non-increasing, and hence, we trade explainability for accuracy. Empirically, we validate that ExKMC produces a low cost clustering, outperforming both standard decision tree methods and other algorithms for explainable clustering. Implementation of ExKMC available at https://github.com/navefr/ExKMC.

With the advent of GDPR, the domain of explainable AI and model interpretability has gained added impetus. Methods to extract and communicate visibility into decision-making models have become legal requirement. Two specific types of explanations, contrastive and counterfactual have been identified as suitable for human understanding. In this paper, we propose a model agnostic method and its systemic implementation to generate these explanations using shapely additive explanations (SHAP). We discuss a generative pipeline to create contrastive explanations and use it to further to generate counterfactual datapoints. This pipeline is tested and discussed on the IRIS, Wine Quality & Mobile Features dataset. Analysis of the results obtained follows.

Learning from class imbalanced datasets poses challenges for many machine learning algorithms. Many real-world domains are, by definition, class imbalanced by virtue of having a majority class that naturally has many more instances than its minority class (e.g. genuine bank transactions occur much more often than fraudulent ones). Many methods have been proposed to solve the class imbalance problem, among the most popular being oversampling techniques (such as SMOTE). These methods generate synthetic instances in the minority class, to balance the dataset, performing data augmentations that improve the performance of predictive machine learning (ML) models. In this paper we advance a novel data augmentation method (adapted from eXplainable AI), that generates synthetic, counterfactual instances in the minority class. Unlike other oversampling techniques, this method adaptively combines exist-ing instances from the dataset, using actual feature-values rather than interpolating values between instances. Several experiments using four different classifiers and 25 datasets are reported, which show that this Counterfactual Augmentation method (CFA) generates useful synthetic data points in the minority class. The experiments also show that CFA is competitive with many other oversampling methods many of which are variants of SMOTE. The basis for CFAs performance is discussed, along with the conditions under which it is likely to perform better or worse in future tests.

The problem of individualization is recognized as crucial in almost every field. Identifying causes of effects in specific events is likewise essential for accurate decision making. However, such estimates invoke counterfactual relationships, and are therefore indeterminable from population data. For example, the probability of benefiting from a treatment concerns an individual having a favorable outcome if treated and an unfavorable outcome if untreated. Experiments conditioning on fine-grained features are fundamentally inadequate because we can't test both possibilities for an individual. Tian and Pearl provided bounds on this and other probabilities of causation using a combination of experimental and observational data. Even though those bounds were proven tight, narrower bounds, sometimes significantly so, can be achieved when structural information is available in the form of a causal model. This has the power to solve central problems, such as explainable AI, legal responsibility, and personalized medicine, all of which demand counterfactual logic. We analyze and expand on existing research by applying bounds to the probability of necessity and sufficiency (PNS) along with graphical criteria and practical applications.

Conceptual understanding through efficient inverse-design of quantum optical experiments

Mario Krenn, Jakob Kottmann, Nora Tischler +1

One crucial question within artificial intelligence research is how this technology can be used to discover new scientific concepts and ideas. We present Theseus, an explainable AI algorithm that can contribute to science at a conceptual level. This work entails four significant contributions. (i) We introduce an interpretable representation of quantum optical experiments amenable to algorithmic use. (ii) We develop an inverse-design approach for new quantum experiments, which is orders of magnitudes faster than the best previous methods. (iii) We solve several crucial open questions in quantum optics, which is expected to advance photonic technology. Finally, and most importantly, (iv) the interpretable representation and drastic speedup produce solutions that a human scientist can interpret outright to discover new scientific concepts. We anticipate that Theseus will become an essential tool in quantum optics and photonic hardware, with potential applicability to other quantum physical disciplines.

Work on "learning with rationales" shows that humans providing explanations to a machine learning system can improve the system's predictive accuracy. However, this work has not been connected to work in "explainable AI" which concerns machines explaining their reasoning to humans. In this work, we show that learning with rationales can also improve the quality of the machine's explanations as evaluated by human judges. Specifically, we present experiments showing that, for CNN- based text classification, explanations generated using "supervised attention" are judged superior to explanations generated using normal unsupervised attention.