Research Papers

Innovative HealthTech teams develop Artificial Intelligence (AI) systems in contexts where ethical expectations and organizational priorities must be balanced under severe resource constraints. While Responsible AI practices are expected to guide the design and evaluation of such systems, they frequently remain abstract or poorly aligned with the operational realities of early-stage innovation. At the ecosystem level, this misalignment disproportionately affects disadvantaged projects and founders, therefore limiting the diversity of problem-areas under consideration, solutions, stakeholder perspectives, and population datasets represented in AI-enabled healthcare systems. Visualization provides a practical mechanism for supporting decision-making across the AI lifecycle. When developed via a rigorous and collaborative design process, structured on domain knowledge and designed around real-world constraints, visual interfaces can operate as effective sociotechnical governance artifacts enabling responsible decision-making. Grounded in innovation-oriented Human-Centered Computing methodologies, we synthesize insights from a series of design studies conducted via a longitudinal visualization research program, a case study centered on governance dashboard design in a translational setting, and a survey of a cohort of early-stage HealthTech startups. Based on these findings, we articulate design process implications for governance-oriented visualization systems: co-creation with stakeholders, alignment with organizational maturity and context, and support for heterogeneous roles and tasks among others. This work contributes actionable guidance for designing Responsible AI governance dashboards that support decision-making and accountability in early-stage health innovation, and suggests that ecosystem-level coordination can enable more scalable and diverse AI innovation in healthcare.

As financial institutions increasingly adopt machine learning for credit risk assessment, the persistence of algorithmic bias remains a critical barrier to equitable financial inclusion. This study provides a comprehensive audit of structural gender bias within the Taiwan Credit Default dataset, specifically challenging the prevailing doctrine of "fairness through blindness." Despite the removal of explicit protected attributes and the application of industry standard fairness interventions, our results demonstrate that gendered predictive signals remain deeply embedded within non-sensitive features. Utilizing SHAP (SHapley Additive exPlanations), we identify that variables such as Marital Status, Age, and Credit Limit function as potent proxies for gender, allowing models to maintain discriminatory pathways while appearing statistically fair. To mathematically quantify this leakage, we employ an adversarial inverse modeling framework. Our findings reveal that the protected gender attribute can be reconstructed from purely non-sensitive financial features with an ROC AUC score of 0.65, demonstrating that traditional fairness audits are insufficient for detecting implicit structural bias. These results advocate for a shift from surface-level statistical parity toward causal-aware modeling and structural accountability in financial AI.

The climate crisis requires responses that integrate scientific, ethical, social, and technological perspectives. Artificial intelligence (AI) has emerged as a powerful tool in climate modelling, environmental monitoring, and energy optimisation, yet its growing use also raises critical environmental, ethical, legal, and social questions. This contribution examines the ambivalent role of AI in the ecological crisis, addressing both its promises and its risks. On the one hand, AI supports improvements in climate forecasting, renewable energy management, and real-time detection of environmental degradation. On the other hand, the energy demands of data centres, resource-intensive hardware production, algorithmic bias, corporate concentration of power, and technocratic decision-making reveal contradictions that challenge its sustainability. The discussion explores these issues through interdisciplinary lenses, including environmental ethics, philosophy of technology, and legal governance, and concludes with recommendations for socially just, ecologically responsible, and democratically accountable uses of AI. Rather than assuming AI as an inherently sustainable solution, this analysis argues that its contribution to climate action depends fundamentally on the values, institutions, and power structures that shape its development.

This white paper examines the technical foundations of European AI standardization under the AI Act. It explains how harmonized standards enable the presumption of conformity mechanism, describes the CEN/CENELEC standardization process, and analyzes why AI poses unique standardization challenges including stochastic behavior, data dependencies, immature evaluation practices, and lifecycle dynamics. The paper argues that AI systems are typically components within larger sociotechnical systems, requiring a layered approach where horizontal standards define process obligations and evidence structures while sectoral profiles specify domain-specific thresholds and acceptance criteria. It proposes a workable scheme based on risk management, reproducible technical checks redefined as stability of measured properties, structured documentation, comprehensive logging, and assurance cases that evolve over the system lifecycle. The paper demonstrates that despite methodological difficulties, technical standards remain essential for translating legal obligations into auditable engineering practice and enabling scalable conformity assessment across providers, assessors, and enforcement authorities

AI Agents vs. Human Investigators: Balancing Automation, Security, and Expertise in Cyber Forensic Analysis

Sneha Sudhakaran, Naresh Kshetri

In an era where cyber threats are rapidly evolving, the reliability of cyber forensic analysis has become increasingly critical for effective digital investigations and cybersecurity responses. AI agents are being adopted across digital forensic practices due to their ability to automate processes such as anomaly detection, evidence classification, and behavioral pattern recognition, significantly enhancing scalability and reducing investigation timelines. However, the characteristics that make AI indispensable also introduce notable risks. AI systems, often trained on biased or incomplete datasets, can produce misleading results, including false positives and false negatives, thereby jeopardizing the integrity of forensic investigations. This study presents a meticulous comparative analysis of the effectiveness of the most used AI agent, ChatGPT, and human forensic investigators in the realm of cyber forensic analysis. Our research reveals critical limitations within AI-driven approaches, demonstrating scenarios in which sophisticated or novel cyber threats remain undetected due to the rigid pattern-based nature of AI systems. Conversely, our analysis highlights the crucial role that human forensic investigators play in mitigating these risks. Through adaptive decision-making, ethical reasoning, and contextual understanding, human investigators effectively identify subtle anomalies and threats that may evade automated detection systems. To reinforce our findings, we conducted comprehensive reliability testing of forensic techniques using multiple cyber threat scenarios. These tests confirmed that while AI agents significantly improve the efficiency of routine analyses, human oversight remains crucial in ensuring accuracy and comprehensiveness of the results.

While Large Language Models (LLMs) produce highly nuanced text simplifications, developers currently lack tools for a holistic, efficient, and reproducible diagnosis of their behavior. This paper introduces the Simplification Profiler, a diagnostic toolkit that generates a multidimensional, interpretable fingerprint of simplified texts. Multiple aggregated simplifications of a model result in a model's fingerprint. This novel evaluation paradigm is particularly vital for languages, where the data scarcity problem is magnified when creating flexible models for diverse target groups rather than a single, fixed simplification style. We propose that measuring a model's unique behavioral signature is more relevant in this context as an alternative to correlating metrics with human preferences. We operationalize this with a practical meta-evaluation of our fingerprints' descriptive power, which bypasses the need for large, human-rated datasets. This test measures if a simple linear classifier can reliably identify various model configurations by their created simplifications, confirming that our metrics are sensitive to a model's specific characteristics. The Profiler can distinguish high-level behavioral variations between prompting strategies and fine-grained changes from prompt engineering, including few-shot examples. Our complete feature set achieves classification F1-scores up to 71.9 %, improving upon simple baselines by over 48 percentage points. The Simplification Profiler thus offers developers a granular, actionable analysis to build more effective and truly adaptive text simplification systems.

Glioblastoma, IDH-wildtype (GBM-IDHwt) is the most common malignant brain tumor. While histomorphology is a crucial component of GBM-IDHwt diagnosis, it is not further considered for prognosis. Here, we present an explainable artificial intelligence (AI) framework to identify and interpret histomorphological features associated with patient survival. The framework combines an explainable multiple instance learning (MIL) architecture that directly identifies prognostically relevant image tiles with a sparse autoencoder (SAE) that maps these tiles to interpretable visual patterns. The MIL model was trained and evaluated on a new real-world dataset of 720 GBM-IDHwt cases from three hospitals and four cancer registries across Germany. The SAE was trained on 1,878 whole-slide images from five independent public glioblastoma collections. Despite the many factors influencing survival time, our method showed some ability to discriminate between patients living less than 180 days or more than 360 days solely based on histomorphology (AUC: 0.67; 95% CI: 0.63-0.72). Cox proportional hazards regression confirmed a significant survival difference between predicted groups after adjustment for established prognostic factors (hazard ratio: 1.47; 95% CI: 1.26-1.72). Three neuropathologists categorized the identified visual patterns into seven distinct histomorphological groups, revealing both established prognostic features and unexpected associations, the latter being potentially attributable to surgery-related confounders. The presented explainable AI framework facilitates prognostic biomarker discovery in GBM-IDHwt and beyond, highlighting promising histomorphological features for further analysis and exposing potential confounders that would be hidden in black-box models.

A Novel Approach to Explainable AI with Quantized Active Ingredients in Decision Making

A. M. A. S. D. Alagiyawanna, Asoka Karunananda, Thushari Silva +1

Artificial Intelligence (AI) systems have shown good success at classifying. However, the lack of explainability is a true and significant challenge, especially in high-stakes domains, such as health and finance, where understanding is paramount. We propose a new solution to this challenge: an explainable AI framework based on our comparative study with Quantum Boltzmann Machines (QBMs) and Classical Boltzmann Machines (CBMs). We leverage principles of quantum computing within classical machine learning to provide substantive transparency around decision-making. The design involves training both models on a binarised and dimensionally reduced MNIST dataset, where Principal Component Analysis (PCA) is applied for preprocessing. For interpretability, we employ gradient-based saliency maps in QBMs and SHAP (SHapley Additive exPlanations) in CBMs to evaluate feature attributions.QBMs deploy hybrid quantum-classical circuits with strongly entangling layers, allowing for richer latent representations, whereas CBMs serve as a classical baseline that utilises contrastive divergence. Along the way, we found that QBMs outperformed CBMs on classification accuracy (83.5% vs. 54%) and had more concentrated distributions in feature attributions as quantified by entropy (1.27 vs. 1.39). In other words, QBMs not only produced better predictive performance than CBMs, but they also provided clearer identification of "active ingredient" or the most important features behind model predictions. To conclude, our results illustrate that quantum-classical hybrid models can display improvements in both accuracy and interpretability, which leads us toward more trustworthy and explainable AI systems.

Asymptotic Universal Alignment: A New Alignment Framework via Test-Time Scaling

Yang Cai, Weiqiang Zheng

Aligning large language models (LLMs) to serve users with heterogeneous and potentially conflicting preferences is a central challenge for personalized and trustworthy AI. We formalize an ideal notion of universal alignment through test-time scaling: for each prompt, the model produces $k\ge 1$ candidate responses and a user selects their preferred one. We introduce $(k,f(k))$-robust alignment, which requires the $k$-output model to have win rate $f(k)$ against any other single-output model, and asymptotic universal alignment (U-alignment), which requires $f(k)\to 1$ as $k\to\infty$. Our main result characterizes the optimal convergence rate: there exists a family of single-output policies whose $k$-sample product policies achieve U-alignment at rate $f(k)=\frac{k}{k+1}$, and no method can achieve a faster rate in general. We show that popular post-training methods, including Nash learning from human feedback (NLHF), can fundamentally underutilize the benefits of test-time scaling. Even though NLHF is optimal for $k=1$, sampling from the resulting (often deterministic) policy cannot guarantee win rates above $\tfrac{1}{2}$ except for an arbitrarily small slack. This stems from a lack of output diversity: existing alignment methods can collapse to a single majority-preferred response, making additional samples redundant. In contrast, our approach preserves output diversity and achieves the optimal test-time scaling rate. In particular, we propose a family of symmetric multi-player alignment games and prove that any symmetric Nash equilibrium policy of the $(k+1)$-player alignment game achieves the optimal $(k,\frac{k}{k+1})$-robust alignment. Finally, we provide theoretical convergence guarantees for self-play learning dynamics in these games and extend the framework to opponents that also generate multiple responses.

This paper examines refusal behavior in generative AI systems through a governance lens. Drawing on historical frameworks of censorship and contemporary design logics, it argues that refusal is not a neutral safeguard but a site of power, shaped by institutional risk management and opaque decision-making. The analysis concludes with user-centered recommendations for ethical refusal design. Keywords: Generative AI governance, AI refusal behavior, Censorship, Ethical design

Glioblastoma (GBM) is a highly aggressive primary brain tumor with limited therapeutic options and poor prognosis. The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter is a critical molecular biomarker that influences patient response to temozolomide chemotherapy. Traditional methods for determining MGMT status rely on invasive biopsies and are limited by intratumoral heterogeneity and procedural risks. This study presents a radiogenomic molecular imaging analysis framework for the non-invasive prediction of MGMT promoter methylation using multi-parametric magnetic resonance imaging (mpMRI). Our approach integrates radiomics, deep learning, and explainable artificial intelligence (XAI) to analyze MRI-derived imaging phenotypes and correlate them with molecular labels. Radiomic features are extracted from FLAIR, T1-weighted, T1-contrast-enhanced, and T2-weighted MRI sequences, while a 3D convolutional neural network learns deep representations from the same modalities. These complementary features are fused using both early fusion and attention-based strategies and classified to predict MGMT methylation status. To enhance clinical interpretability, we apply XAI methods such as Grad-CAM and SHAP to visualize and explain model decisions. The proposed framework is trained on the RSNA-MICCAI Radiogenomic Classification dataset and externally validated on the BraTS 2021 dataset. This work advances the field of molecular imaging by demonstrating the potential of AI-driven radiogenomics for precision oncology, supporting non-invasive, accurate, and interpretable prediction of clinically actionable molecular biomarkers in GBM.

While machine learning shows promise for maternal health risk prediction, clinical adoption in resource-constrained settings faces a critical barrier: lack of explainability and trust. This study presents a hybrid explainable AI (XAI) framework combining ante-hoc fuzzy logic with post-hoc SHAP explanations, validated through systematic clinician feedback. We developed a fuzzy-XGBoost model on 1,014 maternal health records, achieving 88.67% accuracy (ROC-AUC: 0.9703). A validation study with 14 healthcare professionals in Bangladesh revealed strong preference for hybrid explanations (71.4% across three clinical cases) with 54.8% expressing trust for clinical use. SHAP analysis identified healthcare access as the primary predictor, with the engineered fuzzy risk score ranking third, validating clinical knowledge integration (r=0.298). Clinicians valued integrated clinical parameters but identified critical gaps: obstetric history, gestational age, and connectivity barriers. This work demonstrates that combining interpretable fuzzy rules with feature importance explanations enhances both utility and trust, providing practical insights for XAI deployment in maternal healthcare.