Research Papers

LAVA: Granular Neuron-Level Explainable AI for Alzheimer's Disease Assessment from Fundus Images

Nooshin Yousefzadeh, Charlie Tran, Adolfo Ramirez-Zamora +3

Alzheimer's Disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia. Early diagnosis is critical for patients to benefit from potential intervention and treatment. The retina has been hypothesized as a diagnostic site for AD detection owing to its anatomical connection with the brain. Developed AI models for this purpose have yet to provide a rational explanation about the decision and neither infer the stage of disease's progression. Along this direction, we propose a novel model-agnostic explainable-AI framework, called Granular Neuron-level Explainer (LAVA), an interpretation prototype that probes into intermediate layers of the Convolutional Neural Network (CNN) models to assess the AD continuum directly from the retinal imaging without longitudinal or clinical evaluation. This method is applied to validate the retinal vasculature as a biomarker and diagnostic modality for Alzheimer's Disease (AD) evaluation. UK Biobank cognitive tests and vascular morphological features suggest LAVA shows strong promise and effectiveness in identifying AD stages across the progression continuum.

Metabolic (dysfunction) associated fatty liver disease (MAFLD) establishes new criteria for diagnosing fatty liver disease independent of alcohol consumption and concurrent viral hepatitis infection. However, the long-term outcome of MAFLD subjects is sparse. Few articles are focused on mortality in MAFLD subjects, and none investigate how to predict a fatal outcome. In this paper, we propose an artificial intelligence-based framework named MAFUS that physicians can use for predicting mortality in MAFLD subjects. The framework uses data from various anthropometric and biochemical sources based on Machine Learning (ML) algorithms. The framework has been tested on a state-of-the-art dataset on which five ML algorithms are trained. Support Vector Machines resulted in being the best model. Furthermore, an Explainable Artificial Intelligence (XAI) analysis has been performed to understand the SVM diagnostic reasoning and the contribution of each feature to the prediction. The MAFUS framework is easy to apply, and the required parameters are readily available in the dataset.

Through a user study in the field of livestock farming, we verify the effectiveness of an XAI framework for video surveillance systems. The systems can be made interpretable by incorporating experts' decision-making processes. AI systems are becoming increasingly common in real-world applications, especially in fields related to human decision-making, and its interpretability is necessary. However, there are still relatively few standard methods for assessing and addressing the interpretability of machine learning-based systems in real-world applications. In this study, we examine the framework of a video surveillance AI system that presents the reasoning behind predictions by incorporating experts' decision-making processes with rich domain knowledge of the notification target. While general black-box AI systems can only present final probability values, the proposed framework can present information relevant to experts' decisions, which is expected to be more helpful for their decision-making. In our case study, we designed a system for detecting signs of calving in cattle based on the proposed framework and evaluated the system through a user study (N=6) with people involved in livestock farming. A comparison with the black-box AI system revealed that many participants referred to the presented reasons for the prediction results, and five out of six participants selected the proposed system as the system they would like to use in the future. It became clear that we need to design a user interface that considers the reasons for the prediction results.

The recognition or understanding of the scenes observed with a SAR system requires a broader range of cues, beyond the spatial context. These encompass but are not limited to: imaging geometry, imaging mode, properties of the Fourier spectrum of the images or the behavior of the polarimetric signatures. In this paper, we propose a change of paradigm for explainability in data science for the case of Synthetic Aperture Radar (SAR) data to ground the explainable AI for SAR. It aims to use explainable data transformations based on well-established models to generate inputs for AI methods, to provide knowledgeable feedback for training process, and to learn or improve high-complexity unknown or un-formalized models from the data. At first, we introduce a representation of the SAR system with physical layers: i) instrument and platform, ii) imaging formation, iii) scattering signatures and objects, that can be integrated with an AI model for hybrid modeling. Successively, some illustrative examples are presented to demonstrate how to achieve hybrid modeling for SAR image understanding. The perspective of trustworthy model and supplementary explanations are discussed later. Finally, we draw the conclusion and we deem the proposed concept has applicability to the entire class of coherent imaging sensors and other computational imaging systems.

MixBoost: Improving the Robustness of Deep Neural Networks by Boosting Data Augmentation

Zhendong Liu, Wenyu Jiang, Min guo +1

As more and more artificial intelligence (AI) technologies move from the laboratory to real-world applications, the open-set and robustness challenges brought by data from the real world have received increasing attention. Data augmentation is a widely used method to improve model performance, and some recent works have also confirmed its positive effect on the robustness of AI models. However, most of the existing data augmentation methods are heuristic, lacking the exploration of their internal mechanisms. We apply the explainable artificial intelligence (XAI) method, explore the internal mechanisms of popular data augmentation methods, analyze the relationship between game interactions and some widely used robustness metrics, and propose a new proxy for model robustness in the open-set environment. Based on the analysis of the internal mechanisms, we develop a mask-based boosting method for data augmentation that comprehensively improves several robustness measures of AI models and beats state-of-the-art data augmentation approaches. Experiments show that our method can be widely applied to many popular data augmentation methods. Different from the adversarial training, our boosting method not only significantly improves the robustness of models, but also improves the accuracy of test sets. Our code is available at \url{https://github.com/Anonymous_for_submission}.

Artificial intelligence is creating one of the biggest revolution across technology driven application fields. For the finance sector, it offers many opportunities for significant market innovation and yet broad adoption of AI systems heavily relies on our trust in their outputs. Trust in technology is enabled by understanding the rationale behind the predictions made. To this end, the concept of eXplainable AI emerged introducing a suite of techniques attempting to explain to users how complex models arrived at a certain decision. For cross-sectional data classical XAI approaches can lead to valuable insights about the models' inner workings, but these techniques generally cannot cope well with longitudinal data (time series) in the presence of dependence structure and non-stationarity. We here propose a novel XAI technique for deep learning methods which preserves and exploits the natural time ordering of the data.

As the applications of Natural Language Processing (NLP) in sensitive areas like Political Profiling, Review of Essays in Education, etc. proliferate, there is a great need for increasing transparency in NLP models to build trust with stakeholders and identify biases. A lot of work in Explainable AI has aimed to devise explanation methods that give humans insights into the workings and predictions of NLP models. While these methods distill predictions from complex models like Neural Networks into consumable explanations, how humans understand these explanations is still widely unexplored. Innate human tendencies and biases can handicap the understanding of these explanations in humans, and can also lead to them misjudging models and predictions as a result. We designed a randomized survey-based experiment to understand the effectiveness of saliency-based Post-hoc explainability methods in Natural Language Processing. The result of the experiment showed that humans have a tendency to accept explanations with a less critical view.

Accurate wind turbine power curve models, which translate ambient conditions into turbine power output, are crucial for wind energy to scale and fulfill its proposed role in the global energy transition. While machine learning (ML) methods have shown significant advantages over parametric, physics-informed approaches, they are often criticised for being opaque 'black boxes', which hinders their application in practice. We apply Shapley values, a popular explainable artificial intelligence (XAI) method, and the latest findings from XAI for regression models, to uncover the strategies ML models have learned from operational wind turbine data. Our findings reveal that the trend towards ever larger model architectures, driven by a focus on test set performance, can result in physically implausible model strategies. Therefore, we call for a more prominent role of XAI methods in model selection. Moreover, we propose a practical approach to utilize explanations for root cause analysis in the context of wind turbine performance monitoring. This can help to reduce downtime and increase the utilization of turbines in the field.

Reinforcement learning (RL) is already widely applied to applications such as robotics, but it is only sparsely used in sensor management. In this paper, we apply the popular Proximal Policy Optimization (PPO) approach to a multi-agent UAV tracking scenario. While recorded data of real scenarios can accurately reflect the real world, the required amount of data is not always available. Simulation data, however, is typically cheap to generate, but the utilized target behavior is often naive and only vaguely represents the real world. In this paper, we utilize multi-agent RL to jointly generate protagonistic and antagonistic policies and overcome the data generation problem, as the policies are generated on-the-fly and adapt continuously. This way, we are able to clearly outperform baseline methods and robustly generate competitive policies. In addition, we investigate explainable artificial intelligence (XAI) by interpreting feature saliency and generating an easy-to-read decision tree as a simplified policy.

Explainable AI (XAI) methods are frequently applied to obtain qualitative insights about deep models' predictions. However, such insights need to be interpreted by a human observer to be useful. In this paper, we aim to use explanations directly to make decisions without human observers. We adopt two gradient-based explanation methods, Integrated Gradients (IG) and backprop, for the task of 3D object detection. Then, we propose a set of quantitative measures, named Explanation Concentration (XC) scores, that can be used for downstream tasks. These scores quantify the concentration of attributions within the boundaries of detected objects. We evaluate the effectiveness of XC scores via the task of distinguishing true positive (TP) and false positive (FP) detected objects in the KITTI and Waymo datasets. The results demonstrate an improvement of more than 100\% on both datasets compared to other heuristics such as random guesses and the number of LiDAR points in the bounding box, raising confidence in XC's potential for application in more use cases. Our results also indicate that computationally expensive XAI methods like IG may not be more valuable when used quantitatively compare to simpler methods.

Do We Need Explainable AI in Companies? Investigation of Challenges, Expectations, and Chances from Employees' Perspective

Katharina Weitz, Chi Tai Dang, Elisabeth André

Companies' adoption of artificial intelligence (AI) is increasingly becoming an essential element of business success. However, using AI poses new requirements for companies and their employees, including transparency and comprehensibility of AI systems. The field of Explainable AI (XAI) aims to address these issues. Yet, the current research primarily consists of laboratory studies, and there is a need to improve the applicability of the findings to real-world situations. Therefore, this project report paper provides insights into employees' needs and attitudes towards (X)AI. For this, we investigate employees' perspectives on (X)AI. Our findings suggest that AI and XAI are well-known terms perceived as important for employees. This recognition is a critical first step for XAI to potentially drive successful usage of AI by providing comprehensible insights into AI technologies. In a lessons-learned section, we discuss the open questions identified and suggest future research directions to develop human-centered XAI designs for companies. By providing insights into employees' needs and attitudes towards (X)AI, our project report contributes to the development of XAI solutions that meet the requirements of companies and their employees, ultimately driving the successful adoption of AI technologies in the business context.

Objectives: The present study evaluated the impact of a commercially available explainable AI algorithm in augmenting the ability of clinicians to identify lung cancer on chest X-rays (CXR). Design: This retrospective study evaluated the performance of 11 clinicians for detecting lung cancer from chest radiographs, with and without assistance from a commercially available AI algorithm (red dot, Behold.ai) that predicts suspected lung cancer from CXRs. Clinician performance was evaluated against clinically confirmed diagnoses. Setting: The study analysed anonymised patient data from an NHS hospital; the dataset consisted of 400 chest radiographs from adult patients (18 years and above) who had a CXR performed in 2020, with corresponding clinical text reports. Participants: A panel of readers consisting of 11 clinicians (consultant radiologists, radiologist trainees and reporting radiographers) participated in this study. Main outcome measures: Overall accuracy, sensitivity, specificity and precision for detecting lung cancer on CXRs by clinicians, with and without AI input. Agreement rates between clinicians and performance standard deviation were also evaluated, with and without AI input. Results: The use of the AI algorithm by clinicians led to an improved overall performance for lung tumour detection, achieving an overall increase of 17.4% of lung cancers being identified on CXRs which would have otherwise been missed, an overall increase in detection of smaller tumours, a 24% and 13% increased detection of stage 1 and stage 2 lung cancers respectively, and standardisation of clinician performance. Conclusions: This study showed great promise in the clinical utility of AI algorithms in improving early lung cancer diagnosis and promoting health equity through overall improvement in reader performances, without impacting downstream imaging resources.