Research Papers

Scientific Explanations in Health Sciences: Causality, Trust, and Epistemic Adequacy

Martina Mattioli, Marcello Pelillo

Medical Artificial Intelligence (AI) is widely expected to transform clinical practice, yet the decision-making processes of many Machine Learning (ML) models remain opaque. Explainability has been advanced as a partial remedy to clarify why AI generates predictions, particularly in high-stakes contexts. Despite ongoing efforts, debates on what constitutes an adequate medical explanation remain unsettled. Yet, explanation has long been a central topic of inquiry in the philosophy of science and medicine. The insights developed in these fields, however, have been largely overlooked in contemporary explainable AI (XAI) research, leaving its foundational assumptions insufficiently examined. To address this gap, this paper develops a critical review at the intersection of philosophy of science and XAI. It examines prevailing accounts of what counts as an explanation in the health sciences and assesses their adequacy for informing XAI in medicine, arguing that they provide necessary conditions for a philosophically grounded approach to explainability in this domain. Building on this foundational philosophical literature, the discussion identifies three central axes of analysis: the role of causality in medical reasoning, the epistemic and relational dimensions of medical trust, and the criteria of explanatory adequacy as shaped by the pragmatic needs of diverse stakeholders. By integrating philosophical analysis with current developments in medical AI, the paper outlines principles for designing XAI systems that offer explanations that are not only epistemically robust but also aligned with the epistemic and practical requirements of clinical decision-making, shaping ongoing debates in medical XAI toward underexplored conceptual foundations.

A Fair and Transparent Framework for Speech-Based Depression Detection: Balancing Interpretability and Performance

Mariel Estevez, Alfonso Ortega, Antonio Miguel +1

While speech provides rich, non-invasive biomarkers for mental-health assessment, clinical adoption is limited by opaque models and potential demographic bias. In this work we propose a methodological framework to evaluate robustness and interpretability for automated depression detection on the extended DAIC-WOZ dataset using low-complexity machine learning baselines (RF, SVM, and MLP) chosen to mitigate overfitting and enhance generalization in combination with human-understandable acoustic features (MFCCs, eGeMAPS). To balance accuracy with clinical trust, we leverage explainability methods (LIME and SHAP) for feature selection, validating our findings with statistical significance tests and demographic fairness analyses to mitigate spurious, artifact-driven correlations. Empirical results demonstrate that an optimized subset of explainable AI (XAI)-selected features combined with an MLP architecture achieves a state-of-the-art test accuracy of 82\%. Ultimately, this work provides a transparent framework for robust and ethical assistive technologies that can be applied to any other binary task.

Speech conveys rich emotional information. As Speech Emotion Recognition (SER) is usually deployed in privacy-sensitive and reliability-critical environments, adversarial attacks on SER have attracted increasing attention. Existing sparse attacks control the number of perturbed elements, yet, they often lack explainability guidance and explicit measures of explanation consistency. A unified treatment of sparsity and magnitude constraints is also uncommon. In addition, transferability across attack families and target models remains limited. Hence, we propose a SalIency-Guided sparse Mask Attack (SIGMA). On self-supervised speech features, we use post-hoc explainable artificial intelligence (XAI) techniques to produce saliency maps and identify the scope of the mask, and then restrict magnitude-bounded updates to this mask. The mask is computed once and can be reused across models and different sparsity attacks to amortise cost. We evaluate on the IEMOCAP and TESS datasets. Under matched budgets and across multiple sparse-attack settings, SIGMA maintains competitive attack success rates, navigating a conscious trade-off between attack efficacy and explanation consistency. SIGMA therefore provides an efficient and interpretable framework for analysing the vulnerability and explanation behaviour of SER models under structured perturbations.

Explainability in Many-Objective Optimization (MaO) is currently hindered by the escalating complexity of the Pareto front, which renders the relationship between high-dimensional decision variables and objective outcomes increasingly opaque. As the number of objectives exceeds the limits of traditional visualization, decision-makers encounter a ``cognitive drought'' in identifying relevant trade-offs or specifying target regions without a priori knowledge. To bridge this interpretability gap, we introduce the {Partition-Guided Distance Saliency (PGDS)} framework, a novel XAI approach designed for continuous optimization landscapes. Our framework automates the explanation process through a three-stage pipeline that prioritizes geometric intuition over abstract rules. First, we employ a surrogate model that learns how geometric distances in the decision space map to proximity in the objective space. Second, to address the difficulty of manual target selection in high dimensions, the framework automatically partitions the objective landscape into distinct regions and identifies local ``Dominating Points'' to serve as automated targets for improvement. Third, we quantify how sensitive a solution's position is to each decision variable by measuring the distance shifts induced by perturbations to each variable. This allows PGDS to categorize features as either ``Drivers'' which facilitate convergence toward preferred regions, or ``Blockers'' which represent geometric constraints hindering further progress. Validation on 10-objective benchmarks and a physics-informed engineering problem (Welded Beam) demonstrates that PGDS provides differentiated, actionable insights that traditional visualization and rule-based XAI methods fail to provide.

Explainable AI (XAI) is now a major theme in NLP; however, Arabic NLP remains under-explained in three connected senses. First, there is a method gap: Arabic XAI relies heavily on a small set of post-hoc techniques such as LIME, SHAP, attention visualization, and saliency, while broader NLP XAI offers richer diagnostic, counterfactual, probing, rationale-based, and human-centered methods. Second, there is a task gap: existing Arabic XAI work is concentrated in classification tasks, especially sentiment analysis, hate/offensive language detection, fake news, and spam, with weaker coverage of generation, retrieval, translation, summarization, structured prediction, and dialogue. Third, there is a linguistic gap: many explanations identify influential tokens, but rarely explain Arabic-specific phenomena such as morphology, clitics, dialectal variation, diglossia, orthographic ambiguity, diacritics, code-switching, named entities, cultural references, or Classical and religious registers. This critical structured survey synthesizes the reviewed literature on Arabic XAI across text, speech, and multimodal settings. We argue that Arabic NLP does not only need explanations of model decisions; it needs explanations that are faithful to Arabic as a linguistic, cultural, and sociotechnical object. We introduce a taxonomy of tasks, methods, linguistic units, varieties, goals, and evaluation practices, and propose a research agenda for linguistically grounded Arabic XAI.

Concept-based Explainable AI (C-XAI) seeks human-understandable explanations grounded in semantic concepts, yet validation is limited by the scarcity of fine-grained concept annotations. We evaluate whether mid-scale Multimodal Large Language Models (MLLMs) can perform localized concept naming under strict zero-shot conditions by assigning labels to bounding-box regions at both object and part levels. We propose a reproducible zero-shot evaluation protocol for Concept Naming (CoNa) with (i) closed-set, category-constrained prompting for moderate vocabularies and (ii) Open-CoNa, an embedding-similarity-based strategy for large label spaces. Experiments with four MLLMs (7B-32B) show consistent performance trends across datasets, reaching 62%-88% object-level exact-match accuracy, highlighting the potential of training-free concept annotation from localized regions. We discuss limitations and failure modes and release a reproducible framework to support future low-cost C-XAI research.

Artificial intelligence is transforming biodiversity monitoring by enabling automated analysis of ecological imagery collected from camera traps, drones, satellites, underwater platforms, and other sensing systems. These tools can expand the scale and speed of conservation assessments, yet many computer vision models remain difficult to inspect, making it challenging to determine whether predictions are based on ecologically meaningful signals or on spurious correlations, sampling biases, and other artifacts that may undermine conservation decisions. We argue that explainable artificial intelligence (XAI) should become a standard component of ecological model validation because conservation practitioners increasingly depend on understanding not only whether a model is accurate, but why it is accurate. We provide practical guidance for applying XAI to three common ecological computer vision tasks: image classification, object detection, and image segmentation. To illustrate how XAI can support ecological model auditing, refinement, and deployment, we present two case studies using aerial imagery: harbor seal detection and cetacean anatomical segmentation. These examples demonstrate how explanation methods can identify biologically meaningful cues, reveal false positives driven by background and shape confounds, uncover edge and occlusion effects, and guide data collection, augmentation, and retraining strategies. More broadly, they show how explainability can help assess whether model reasoning aligns with ecological understanding. We conclude by identifying key challenges and opportunities. By making model behavior more transparent and scientifically interrogable, XAI can help ensure that AI-supported ecological evidence is more reliable, understandable, and actionable for biodiversity conservation.

Edible insects offer an efficient source of alternative protein, requiring less land, water and emitting less greenhouse gas than conventional livestock. However, their successful integration into the food supply chain demands reliable species authentication to control allergen exposure, prevent adulteration, and meet regulatory standards. Near-infrared spectroscopy provides a rapid analytical tool, but its performance drops when applied to production batches unseen during training due to batch-to-batch variation in spectral measurements. We introduce the Batch-Invariant Spectral Network (BISN), an end-to-end framework that combines a learnable preprocessing module, initialised with Savitzky-Golay filtering, with an entropy-regularised adversarial objective to suppress batch-specific spectral variation. In contrast to Domain-Adversarial Neural Networks, which enforce domain adaptation only after feature extraction, BISN suppress batch-effects before species-specific features are learned. Using 2,700 spectra from three species (Acheta domesticus, Hermetia illucens, and Tenebrio molitor) collected across three independent production batches, BISN achieves a mean leave-one-batch-out accuracy of 0.93 (standard deviation 0.04), outperforming the strongest baseline by four percent. Further insights gained by using explainable AI confirm that model decisions consistently rely on the lipid and protein absorption regions across all folds, connecting predictive performance to known insect biochemistry. BISN addresses both cross-batch robustness and biochemical interpretability for automated insect species authentication under realistic industrial conditions. The source code and dataset are publicly available at https://github.com/majharB/bisn.

While many explainable AI (XAI) methods have been proposed, most are not designed for time-series forecasting models and often rely on the implicit assumption that timestamp features are independent. This assumption ignores the fundamental property of temporal dependence and can lead to explanations that violate the sequential and causal structure of the data. We introduce \textsc{KARMA}, a method for explaining time-series predictors by constructing a Markov surrogate model that captures the temporal dependencies learned by the predictor. Our approach revolves around three main aspects: identifying the minimal history length $K$ that is predictively sufficient for the model, estimating the best-fitting $K$-order Markov transition kernel from the discretized history space, and a five-level global explanation hierarchy that can be derived from the Markov transition kernel, which we illustrate using real-world weather data (Beijing PM 2.5). We also certify using complex synthetic data with known true causal edges that KARMA (i) recovers the data causal structure as learned by the model via a controlled experiment and (ii) identifies temporal dependencies better than established attribution methods such as TimeSHAP.

One of the significant mental health issues affecting female sex workers (FSWs) is mental disorders, especially depression. Exposure to violence, stigma, and economic hardship further increases their psychological risk. Current machine learning (ML) models are typically ineffective at capturing the high-dimensional and complex risk patterns that exist in this marginalized group. This paper suggests a hybrid predictive model that merges an ensemble feature selection strategy using ANOVA and mutual information and Harris Hawks optimization-tuned logistic regression and represents a new application of swarm intelligence to predict mental health in vulnerable groups. The explainable AI (XAI) methods can be used to understand the factors of trauma associated with model predictions. When applied to a group of 3,005 FSWs, it can be seen that the proposed model is more effective than traditional classifiers, with an accuracy of 95.78%, an F1 score of 95.77%, and an AUC of 0.96, and identifying post-traumatic stress, client-related violence, and occupational factors as major contributors to depression. This work bridges the gaps between conventional and ML approaches to develop an XAI tool that enables vulnerable groups to receive early assistance, evidence-based targeted psychosocial care, and health planning.

Automated diabetic retinopathy (DR) grading from colour fundus photographs can achieve strong predictive performance, but clinical interpretation requires more than an image-level label. It requires understanding how lesion evidence is distributed around retinal vessels and how this evidence relates to quantitative vascular biomarkers. We present a dual-edge spatial-Jacobian image graph for interpretable DR grading. Each fundus image is represented as a graph node with four aligned evidence streams: AutoMorph vessel information ($X_1$), DR-XAI-style lesion evidence maps ($X_2$), a 128-dimensional lesion-based contrastive image embedding ($X_3$), and AutoMorph morphometric biomarkers ($X_4$). The spatial edge branch ($X_{12}$) encodes vessel-lesion geometry, while the Jacobian branch ($X_{34}$) models embedding-biomarker sensitivity. Lightweight two-token attention fuses both edge families into a final image graph. On 2,910 matched non-augmented APTOS images, the full graph achieves 0.8076 accuracy, 0.8312 quadratic weighted kappa, 0.5915 macro-F1, and 0.9330 adjacent-grade accuracy; referable DR reaches 0.9055 accuracy and 0.9711 AUROC. The framework is positioned as an explainable representation-learning tool for lesion-biomarker hypothesis generation, rather than as a deployment-ready clinical classifier. The code is available at https://github.com/Inamullah-Colab/dual-edge-dr-graph-xai.

Next-generation wireless systems are expected to be ``AI-native," with neural networks (NNs) embedded throughout the physical (PHY) layer protocol stack to improve spectral efficiency, latency, and network autonomy. However, the opacity of deep learning (DL) models raises increasing concerns about system reliability, safety, and privacy, especially under complex and time-varying network environments. This survey studies explainable AI (XAI) in wireless PHY layers from the explainability perspective. We first formalize a series of responsibility-oriented goals for wireless XAI. Then, we develop a systematic taxonomy of explainability approaches and distill practical criteria for deploying explanations in communication scenarios. We provide a comprehensive review of where and how XAI can be applied throughout the PHY layer, connecting representative learning paradigms to appropriate explanation techniques, evaluation metrics, and deployment considerations. Open challenges and future directions are discussed, including explainability-performance tradeoffs, explainability-aware data processing, customized XAI for communication-specific structures, cross-layer explanation consistency, and emerging needs for explaining LLM- and Agentic-AI-driven PHY layers.