Research Papers

Significant investment and development have gone into integrating Artificial Intelligence (AI) in medical and healthcare applications, leading to advanced control systems in medical technology. However, the opacity of AI systems raises concerns about essential characteristics needed in such sensitive applications, like transparency and trustworthiness. Our study addresses these concerns by investigating a process for selecting the most adequate Explainable AI (XAI) methods to comply with the explanation requirements of key EU regulations in the context of smart bioelectronics for medical devices. The adopted methodology starts with categorising smart devices by their control mechanisms (open-loop, closed-loop, and semi-closed-loop systems) and delving into their technology. Then, we analyse these regulations to define their explainability requirements for the various devices and related goals. Simultaneously, we classify XAI methods by their explanatory objectives. This allows for matching legal explainability requirements with XAI explanatory goals and determining the suitable XAI algorithms for achieving them. Our findings provide a nuanced understanding of which XAI algorithms align better with EU regulations for different types of medical devices. We demonstrate this through practical case studies on different neural implants, from chronic disease management to advanced prosthetics. This study fills a crucial gap in aligning XAI applications in bioelectronics with stringent provisions of EU regulations. It provides a practical framework for developers and researchers, ensuring their AI innovations advance healthcare technology and adhere to legal and ethical standards.

AI prevails in financial fraud detection and decision making. Yet, due to concerns about biased automated decision making or profiling, regulations mandate that final decisions are made by humans. Financial fraud investigators face the challenge of manually synthesizing vast amounts of unstructured information, including AI alerts, transaction histories, social media insights, and governmental laws. Current Visual Analytics (VA) systems primarily support isolated aspects of this process, such as explaining binary AI alerts and visualizing transaction patterns, thus adding yet another layer of information to the overall complexity. In this work, we propose a framework where the VA system supports decision makers throughout all stages of financial fraud investigation, including data collection, information synthesis, and human criteria iteration. We illustrate how VA can claim a central role in AI-aided decision making, ensuring that human judgment remains in control while minimizing potential biases and labor-intensive tasks.

Understanding the inner representation of a neural network helps users improve models. Concept-based methods have become a popular choice for explaining deep neural networks post-hoc because, unlike most other explainable AI techniques, they can be used to test high-level visual "concepts" that are not directly related to feature attributes. For instance, the concept of "stripes" is important to classify an image as a zebra. Concept-based explanation methods, however, require practitioners to guess and manually collect multiple candidate concept image sets, making the process labor-intensive and prone to overlooking important concepts. Addressing this limitation, in this paper, we frame concept image set creation as an image generation problem. However, since naively using a standard generative model does not result in meaningful concepts, we devise a reinforcement learning-based preference optimization (RLPO) algorithm that fine-tunes a vision-language generative model from approximate textual descriptions of concepts. Through a series of experiments, we demonstrate our method's ability to efficiently and reliably articulate diverse concepts that are otherwise challenging to craft manually.

The Lunar landing has drawn great interest in lunar exploration in recent years, and autonomous lunar landing navigation is fundamental to this task. AI is expected to play a critical role in autonomous and intelligent space missions, yet human experts question the reliability of AI solutions. Thus, the \gls{xai} for vision-based lunar landing is studied in this paper, aiming at providing transparent and understandable predictions for intelligent lunar landing. Attention-based Darknet53 is proposed as the feature extraction structure. For crater detection and navigation tasks, attention-based YOLOv3 and attention-Darknet53-LSTM are presented respectively. The experimental results show that the offered networks provide competitive performance on relative crater detection and pose estimation during the lunar landing. The explainability of the provided networks is achieved by introducing an attention mechanism into the network during model building. Moreover, the PCC is utilised to quantitively evaluate the explainability of the proposed networks, with the findings showing the functions of various convolutional layers in the network.

To date, several methods have been developed to explain deep learning algorithms for classification tasks. Recently, an adaptation of two of such methods has been proposed to generate instance-level explainable maps in a semantic segmentation scenario, such as multiple sclerosis (MS) lesion segmentation. In the mentioned work, a 3D U-Net was trained and tested for MS lesion segmentation, yielding an F1 score of 0.7006, and a positive predictive value (PPV) of 0.6265. The distribution of values in explainable maps exposed some differences between maps of true and false positive (TP/FP) examples. Inspired by those results, we explore in this paper the use of characteristics of lesion-specific saliency maps to refine segmentation and detection scores. We generate around 21000 maps from as many TP/FP lesions in a batch of 72 patients (training set) and 4868 from the 37 patients in the test set. 93 radiomic features extracted from the first set of maps were used to train a logistic regression model and classify TP versus FP. On the test set, F1 score and PPV were improved by a large margin when compared to the initial model, reaching 0.7450 and 0.7817, with 95% confidence intervals of [0.7358, 0.7547] and [0.7679, 0.7962], respectively. These results suggest that saliency maps can be used to refine prediction scores, boosting a model's performances.

Deep Reinforcement Learning (DRL) is a frequently employed technique to solve scheduling problems. Although DRL agents ace at delivering viable results in short computing times, their reasoning remains opaque. We conduct a case study where we systematically apply two explainable AI (xAI) frameworks, namely SHAP (DeepSHAP) and Captum (Input x Gradient), to describe the reasoning behind scheduling decisions of a specialized DRL agent in a flow production. We find that methods in the xAI literature lack falsifiability and consistent terminology, do not adequately consider domain-knowledge, the target audience or real-world scenarios, and typically provide simple input-output explanations rather than causal interpretations. To resolve this issue, we introduce a hypotheses-based workflow. This approach enables us to inspect whether explanations align with domain knowledge and match the reward hypotheses of the agent. We furthermore tackle the challenge of communicating these insights to third parties by tailoring hypotheses to the target audience, which can serve as interpretations of the agent's behavior after verification. Our proposed workflow emphasizes the repeated verification of explanations and may be applicable to various DRL-based scheduling use cases.

The increasing use of Retrieval-Augmented Generation (RAG) systems in various applications necessitates stringent protocols to ensure RAG systems accuracy, safety, and alignment with user intentions. In this paper, we introduce VERA (Validation and Evaluation of Retrieval-Augmented Systems), a framework designed to enhance the transparency and reliability of outputs from large language models (LLMs) that utilize retrieved information. VERA improves the way we evaluate RAG systems in two important ways: (1) it introduces a cross-encoder based mechanism that encompasses a set of multidimensional metrics into a single comprehensive ranking score, addressing the challenge of prioritizing individual metrics, and (2) it employs Bootstrap statistics on LLM-based metrics across the document repository to establish confidence bounds, ensuring the repositorys topical coverage and improving the overall reliability of retrieval systems. Through several use cases, we demonstrate how VERA can strengthen decision-making processes and trust in AI applications. Our findings not only contribute to the theoretical understanding of LLM-based RAG evaluation metric but also promote the practical implementation of responsible AI systems, marking a significant advancement in the development of reliable and transparent generative AI technologies.

Despite many advances in knowledge engineering (KE), challenges remain in areas such as engineering knowledge graphs (KGs) at scale, keeping up with evolving domain knowledge, multilingualism, and multimodality. Recently, KE has used LLMs to support semi-automatic tasks, but the most effective use of LLMs to support knowledge engineers across the KE activites is still in its infancy. To explore the vision of LLM copilots for KE and change existing KE practices, we conducted a multimethod study during a KE hackathon. We investigated participants' views on the use of LLMs, the challenges they face, the skills they may need to integrate LLMs into their practices, and how they use LLMs responsibly. We found participants felt LLMs could contribute to improving efficiency when engineering KGs, but presented increased challenges around the already complex issues of evaluating the KE tasks. We discovered prompting to be a useful but undervalued skill for knowledge engineers working with LLMs, and note that natural language processing skills may become more relevant across more roles in KG construction. Integrating LLMs into KE tasks needs to be mindful of potential risks and harms related to responsible AI. Given the limited ethical training, most knowledge engineers receive solutions such as our suggested `KG cards' based on data cards could be a useful guide for KG construction. Our findings can support designers of KE AI copilots, KE researchers, and practitioners using advanced AI to develop trustworthy applications, propose new methodologies for KE and operate new technologies responsibly.

Explainable Artificial Intelligence (XAI) is central to the debate on integrating Artificial Intelligence (AI) and Machine Learning (ML) algorithms into clinical practice. High-performing AI/ML models, such as ensemble learners and deep neural networks, often lack interpretability, hampering clinicians' trust in their predictions. To address this, XAI techniques are being developed to describe AI/ML predictions in human-understandable terms. One promising direction is the adaptation of sensitivity analysis (SA) and global sensitivity analysis (GSA), which inherently rank model inputs by their impact on predictions. Here, we introduce a novel delta-XAI method that provides local explanations of ML model predictions by extending the delta index, a GSA metric. The delta-XAI index assesses the impact of each feature's value on the predicted output for individual instances in both regression and classification problems. We formalize the delta-XAI index and provide code for its implementation. The delta-XAI method was evaluated on simulated scenarios using linear regression models, with Shapley values serving as a benchmark. Results showed that the delta-XAI index is generally consistent with Shapley values, with notable discrepancies in models with highly impactful or extreme feature values. The delta-XAI index demonstrated higher sensitivity in detecting dominant features and handling extreme feature values. Qualitatively, the delta-XAI provides intuitive explanations by leveraging probability density functions, making feature rankings clearer and more explainable for practitioners. Overall, the delta-XAI method appears promising for robustly obtaining local explanations of ML model predictions. Further investigations in real-world clinical settings will be conducted to evaluate its impact on AI-assisted clinical workflows.

In this paper we investigate the explainability of transformer models and their plausibility for hate speech and counter speech detection. We compare representatives of four different explainability approaches, i.e., gradient-based, perturbation-based, attention-based, and prototype-based approaches, and analyze them quantitatively with an ablation study and qualitatively in a user study. Results show that perturbation-based explainability performs best, followed by gradient-based and attention-based explainability. Prototypebased experiments did not yield useful results. Overall, we observe that explainability strongly supports the users in better understanding the model predictions.

Antimicrobial Resistance represents a significant challenge in the Intensive Care Unit (ICU), where patients are at heightened risk of Multidrug-Resistant (MDR) infections-pathogens resistant to multiple antimicrobial agents. This study introduces a novel methodology that integrates Gated Recurrent Units (GRUs) with advanced intrinsic and post-hoc interpretability techniques for detecting the onset of MDR in patients across time. Within interpretability methods, we propose Explainable Artificial Intelligence (XAI) approaches to handle irregular Multivariate Time Series (MTS), introducing Irregular Time Shapley Additive Explanations (IT-SHAP), a modification of Shapley Additive Explanations designed for irregular MTS with Recurrent Neural Networks focused on temporal outputs. Our methodology aims to identify specific risk factors associated with MDR in ICU patients. GRU with Hadamard's attention demonstrated high initial specificity and increasing sensitivity over time, correlating with increased nosocomial infection risks during prolonged ICU stays. XAI analysis, enhanced by Hadamard attention and IT-SHAP, identified critical factors such as previous non-resistant cultures, specific antibiotic usage patterns, and hospital environment dynamics. These insights suggest that early detection of at-risk patients can inform interventions such as preventive isolation and customized treatments, significantly improving clinical outcomes. The proposed GRU model for temporal classification achieved an average Receiver Operating Characteristic Area Under the Curve of 78.27 +- 1.26 over time, indicating strong predictive performance. In summary, this study highlights the clinical utility of our methodology, which combines predictive accuracy with interpretability, thereby facilitating more effective healthcare interventions by professionals.

Dementia, a debilitating neurological condition affecting millions worldwide, presents significant diagnostic challenges. In this work, we introduce DEFORMISE, a novel DEep learning Framework for dementia diagnOsis of eldeRly patients using 3D brain Magnetic resonance Imaging (MRI) scans with Optimized Slice sElection. Our approach features a unique technique for selectively processing MRI slices, focusing on the most relevant brain regions and excluding less informative sections. This methodology is complemented by a confidence-based classification committee composed of three novel deep learning models. Tested on the Open OASIS datasets, our method achieved an impressive accuracy of 94.12%, surpassing existing methodologies. Furthermore, validation on the ADNI dataset confirmed the robustness and generalizability of our approach. The use of explainable AI (XAI) techniques and comprehensive ablation studies further substantiate the effectiveness of our techniques, providing insights into the decision-making process and the importance of our methodology. This research offers a significant advancement in dementia diagnosis, providing a highly accurate and efficient tool for clinical applications.