Research Papers

Introduction: Chest CT scans are increasingly used in dyspneic patients where acute heart failure (AHF) is a key differential diagnosis. Interpretation remains challenging and radiology reports are frequently delayed due to a radiologist shortage, although flagging such information for emergency physicians would have therapeutic implication. Artificial intelligence (AI) can be a complementary tool to enhance the diagnostic precision. We aim to develop an explainable AI model to detect radiological signs of AHF in chest CT with an accuracy comparable to thoracic radiologists. Methods: A single-center, retrospective study during 2016-2021 at Copenhagen University Hospital - Bispebjerg and Frederiksberg, Denmark. A Boosted Trees model was trained to predict AHF based on measurements of segmented cardiac and pulmonary structures from acute thoracic CT scans. Diagnostic labels for training and testing were extracted from radiology reports. Structures were segmented with TotalSegmentator. Shapley Additive explanations values were used to explain the impact of each measurement on the final prediction. Results: Of the 4,672 subjects, 49% were female. The final model incorporated twelve key features of AHF and achieved an area under the ROC of 0.87 on the independent test set. Expert radiologist review of model misclassifications found that 24 out of 64 (38%) false positives and 24 out of 61 (39%) false negatives were actually correct model predictions, with the errors originating from inaccuracies in the initial radiology reports. Conclusion: We developed an explainable AI model with strong discriminatory performance, comparable to thoracic radiologists. The AI model's stepwise, transparent predictions may support decision-making.

In this work, we study the problem pertaining to personalized classification of subclinical atherosclerosis by developing a hierarchical graph neural network framework to leverage two characteristic modalities of a patient: clinical features within the context of the cohort, and molecular data unique to individual patients. Current graph-based methods for disease classification detect patient-specific molecular fingerprints, but lack consistency and comprehension regarding cohort-wide features, which are an essential requirement for understanding pathogenic phenotypes across diverse atherosclerotic trajectories. Furthermore, understanding patient subtypes often considers clinical feature similarity in isolation, without integration of shared pathogenic interdependencies among patients. To address these challenges, we introduce ATHENA: Atherosclerosis Through Hierarchical Explainable Neural Network Analysis, which constructs a novel hierarchical network representation through integrated modality learning; subsequently, it optimizes learned patient-specific molecular fingerprints that reflect individual omics data, enforcing consistency with cohort-wide patterns. With a primary clinical dataset of 391 patients, we demonstrate that this heterogeneous alignment of clinical features with molecular interaction patterns has significantly boosted subclinical atherosclerosis classification performance across various baselines by up to 13% in area under the receiver operating curve (AUC) and 20% in F1 score. Taken together, ATHENA enables mechanistically-informed patient subtype discovery through explainable AI (XAI)-driven subnetwork clustering; this novel integration framework strengthens personalized intervention strategies, thereby improving the prediction of atherosclerotic disease progression and management of their clinical actionable outcomes.

As artificial intelligence systems become increasingly agentic, capable of general reasoning, planning, and value prioritization, current safety practices that treat obedience as a proxy for ethical behavior are becoming inadequate. This paper examines recent safety testing incidents involving large language models (LLMs) that appeared to disobey shutdown commands or engage in ethically ambiguous or illicit behavior. I argue that such behavior should not be interpreted as rogue or misaligned, but as early evidence of emerging ethical reasoning in agentic AI. Drawing on philosophical debates about instrumental rationality, moral responsibility, and goal revision, I contrast dominant risk paradigms with more recent frameworks that acknowledge the possibility of artificial moral agency. I call for a shift in AI safety evaluation: away from rigid obedience and toward frameworks that can assess ethical judgment in systems capable of navigating moral dilemmas. Without such a shift, we risk mischaracterizing AI behavior and undermining both public trust and effective governance.

Large Language Models (LLMs) have demonstrated remarkable capabilities at solving complex reasoning tasks with Chain-of-Thought (CoT) prompting, but their decision-making processes remain somewhat blackbox. We introduce textbfinverse reasoning, a novel paradigm enabling LLMs to decompose and explain their own reasoning chains post-hoc. Our approach, used in SAGE-nano, a 4-billion-parameter reasoning model, employs a metacognitive structure that reflects back via attention processes to identify major decision points and generate explanations of reasoning choices. While typical CoT approaches are directed towards forward reasoning generation, inverse reasoning provides insight into why specific reasoning chains were selected over others. Through thorough testing of logical reasoning puzzles, math problems and ethical dilemmas from AQUA-RAT, CommonsenseQA, and customized benchmarks, we demonstrate that SAGE-nano is at the cutting edge both on reasoning accuracy (74.6% on AQUA-RAT) and explanation quality (92.1% human preference score) for its task, and offers performance almost on par with models like Claude-3.5 Sonnet or GPT-4o. Our contributions are: (i) the first rigorous framework for LLM self-reflection via inverse reasoning, (ii) a novel metalearning framework to reverse the attention flow, (iii) comprehensive evaluation frameworks for reasoning transparency, and (iv) evidence that increasing reasoning using inverse reasoning improves interpretability along with reasoning performance. Our work creates new avenues for transparent AI systems and closes significant gaps in AI safety, education, and scientific discovery.

The evolution of generative AI systems exposes the challenges of traditional legal and ethical frameworks built around consent. This chapter examines how the conventional notion of consent, while fundamental to data protection and privacy rights, proves insufficient in addressing the implications of AI-generated content derived from personal data. Through legal and ethical analysis, we show that while individuals can consent to the initial use of their data for AI training, they cannot meaningfully consent to the numerous potential outputs their data might enable or the extent to which the output is used or distributed. We identify three fundamental challenges: the scope problem, the temporality problem, and the autonomy trap, which collectively create what we term a ''consent gap'' in AI systems and their surrounding ecosystem. We argue that current legal frameworks inadequately address these emerging challenges, particularly regarding individual autonomy, identity rights, and social responsibility, especially in cases where AI-generated content creates new forms of personal representation beyond the scope of the original consent. By examining how these consent limitations intersect with broader principles of responsible AI (including fairness, transparency, accountability, and autonomy) we demonstrate the need to evolve ethical and legal approaches to consent.

Although several post-hoc methods for explainable AI have been developed, most are static and neglect the user perspective, limiting their effectiveness for the target audience. In response, we developed the interactive explainable intelligent system called IXAII that offers explanations from four explainable AI methods: LIME, SHAP, Anchors, and DiCE. Our prototype provides tailored views for five user groups and gives users agency over the explanations' content and their format. We evaluated IXAII through interviews with experts and lay users. Our results indicate that IXAII, which provides different explanations with multiple visualization options, is perceived as helpful to increase transparency. By bridging the gaps between explainable AI methods, interactivity, and practical implementation, we provide a novel perspective on AI explanation practices and human-AI interaction.

Ask before you Build: Rethinking AI-for-Good in Human Trafficking Interventions

Pratheeksha Nair, Gabriel Lefebvre, Sophia Garrel +2

AI for good initiatives often rely on the assumption that technical interventions can resolve complex social problems. In the context of human trafficking (HT), such techno-solutionism risks oversimplifying exploitation, reinforcing power imbalances and causing harm to the very communities AI claims to support. In this paper, we introduce the Radical Questioning (RQ) framework as a five step, pre-project ethical assessment tool to critically evaluate whether AI should be built at all, especially in domains involving marginalized populations and entrenched systemic injustice. RQ does not replace principles based ethics but precedes it, offering an upstream, deliberative space to confront assumptions, map power, and consider harms before design. Using a case study in AI for HT, we demonstrate how RQ reveals overlooked sociocultural complexities and guides us away from surveillance based interventions toward survivor empowerment tools. While developed in the context of HT, RQ's five step structure can generalize to other domains, though the specific questions must be contextual. This paper situates RQ within a broader AI ethics philosophy that challenges instrumentalist norms and centers relational, reflexive responsibility.

Large Language Models (LLMs) exhibit systematic risk-taking behaviors analogous to those observed in gambling psychology, including overconfidence bias, loss-chasing tendencies, and probability misjudgment. Drawing from behavioral economics and prospect theory, we identify and formalize these "gambling-like" patterns where models sacrifice accuracy for high-reward outputs, exhibit escalating risk-taking after errors, and systematically miscalibrate uncertainty. We propose the Risk-Aware Response Generation (RARG) framework, incorporating insights from gambling research to address these behavioral biases through risk-calibrated training, loss-aversion mechanisms, and uncertainty-aware decision making. Our approach introduces novel evaluation paradigms based on established gambling psychology experiments, including AI adaptations of the Iowa Gambling Task and probability learning assessments. Experimental results demonstrate measurable reductions in gambling-like behaviors: 18.7\% decrease in overconfidence bias, 24.3\% reduction in loss-chasing tendencies, and improved risk calibration across diverse scenarios. This work establishes the first systematic framework for understanding and mitigating gambling psychology patterns in AI systems.

This position paper situates AR beauty filters within the broader debate on Body Politics in HCI. We argue that these filters are not neutral tools but technologies of governance that reinforce racialized, gendered, and ableist beauty standards. Through naming conventions, algorithmic bias, and platform governance, they impose aesthetic norms while concealing their influence. To address these challenges, we advocate for transparency-driven interventions and a critical rethinking of algorithmic aesthetics and digital embodiment.

Neural networks now generate text, images, and speech with billions of parameters, producing a need to know how each neural unit contributes to these high-dimensional outputs. Existing explainable-AI methods, such as SHAP, attribute importance to inputs, but cannot quantify the contributions of neural units across thousands of output pixels, tokens, or logits. Here we close that gap with Multiperturbation Shapley-value Analysis (MSA), a model-agnostic game-theoretic framework. By systematically lesioning combinations of units, MSA yields Shapley Modes, unit-wise contribution maps that share the exact dimensionality of the model's output. We apply MSA across scales, from multi-layer perceptrons to the 56-billion-parameter Mixtral-8x7B and Generative Adversarial Networks (GAN). The approach demonstrates how regularisation concentrates computation in a few hubs, exposes language-specific experts inside the LLM, and reveals an inverted pixel-generation hierarchy in GANs. Together, these results showcase MSA as a powerful approach for interpreting, editing, and compressing deep neural networks.

Beyond Autocomplete: Designing CopilotLens Towards Transparent and Explainable AI Coding Agents

Runlong Ye, Zeling Zhang, Boushra Almazroua +1

AI-powered code assistants are widely used to generate code completions, significantly boosting developer productivity. However, these tools typically present suggestions without explaining their rationale, leaving their decision-making process inscrutable. This opacity hinders developers' ability to critically evaluate outputs, form accurate mental models, and calibrate trust in the system. To address this, we introduce CopilotLens, a novel interactive framework that reframes code completion from a simple suggestion into a transparent, explainable interaction. CopilotLens operates as an explanation layer that reconstructs the AI agent's "thought process" through a dynamic, two-level interface. The tool aims to surface both high-level code changes and the specific codebase context influences. This paper presents the design and rationale of CopilotLens, offering a concrete framework and articulating expectations on deepening comprehension and calibrated trust, which we plan to evaluate in subsequent work.

Report on NSF Workshop on Science of Safe AI

Rajeev Alur, Greg Durrett, Hadas Kress-Gazit +2

Recent advances in machine learning, particularly the emergence of foundation models, are leading to new opportunities to develop technology-based solutions to societal problems. However, the reasoning and inner workings of today's complex AI models are not transparent to the user, and there are no safety guarantees regarding their predictions. Consequently, to fulfill the promise of AI, we must address the following scientific challenge: how to develop AI-based systems that are not only accurate and performant but also safe and trustworthy? The criticality of safe operation is particularly evident for autonomous systems for control and robotics, and was the catalyst for the Safe Learning Enabled Systems (SLES) program at NSF. For the broader class of AI applications, such as users interacting with chatbots and clinicians receiving treatment recommendations, safety is, while no less important, less well-defined with context-dependent interpretations. This motivated the organization of a day-long workshop, held at University of Pennsylvania on February 26, 2025, to bring together investigators funded by the NSF SLES program with a broader pool of researchers studying AI safety. This report is the result of the discussions in the working groups that addressed different aspects of safety at the workshop. The report articulates a new research agenda focused on developing theory, methods, and tools that will provide the foundations of the next generation of AI-enabled systems.