Research Papers

A decade of rapid advances in artificial intelligence (AI) has opened new opportunities for clinical decision support systems (CDSS), with large language models (LLMs) demonstrating strong reasoning abilities on timely medical tasks. However, clinical texts are often degraded by human errors or failures in automated pipelines, raising concerns about the reliability and fairness of AI-assisted decision-making. Yet the impact of such degradations remains under-investigated, particularly regarding how noise-induced shifts can heighten predictive uncertainty and unevenly affect demographic subgroups. We present a systematic study of state-of-the-art LLMs under diverse text corruption scenarios, focusing on robustness and equity in next-visit diagnosis prediction. To address the challenge posed by the large diagnostic label space, we introduce a clinically grounded label-reduction scheme and a hierarchical chain-of-thought (CoT) strategy that emulates clinicians' reasoning. Our approach improves robustness and reduces subgroup instability under degraded inputs, advancing the reliable use of LLMs in CDSS. We release code at https://github.com/heejkoo9/NECHOv3.

Cross-cultural value alignment frameworks for responsible AI governance: Evidence from China-West comparative analysis

Haijiang Liu, Jinguang Gu, Xun Wu +2

As Large Language Models (LLMs) increasingly influence high-stakes decision-making across global contexts, ensuring their alignment with diverse cultural values has become a critical governance challenge. This study presents a Multi-Layered Auditing Platform for Responsible AI that systematically evaluates cross-cultural value alignment in China-origin and Western-origin LLMs through four integrated methodologies: Ethical Dilemma Corpus for assessing temporal stability, Diversity-Enhanced Framework (DEF) for quantifying cultural fidelity, First-Token Probability Alignment for distributional accuracy, and Multi-stAge Reasoning frameworK (MARK) for interpretable decision-making. Our comparative analysis of 20+ leading models, such as Qwen, GPT-4o, Claude, LLaMA, and DeepSeek, reveals universal challenges-fundamental instability in value systems, systematic under-representation of younger demographics, and non-linear relationships between model scale and alignment quality-alongside divergent regional development trajectories. While China-origin models increasingly emphasize multilingual data integration for context-specific optimization, Western models demonstrate greater architectural experimentation but persistent U.S.-centric biases. Neither paradigm achieves robust cross-cultural generalization. We establish that Mistral-series architectures significantly outperform LLaMA3-series in cross-cultural alignment, and that Full-Parameter Fine-Tuning on diverse datasets surpasses Reinforcement Learning from Human Feedback in preserving cultural variation...

Emotion recognition from social media is critical for understanding public sentiment, but accessing training data has become prohibitively expensive due to escalating API costs and platform restrictions. We introduce an interpretability-guided framework where Shapley Additive Explanations (SHAP) provide principled guidance for LLM-based synthetic data generation. With sufficient seed data, SHAP-guided approach matches real data performance, significantly outperforms naïve generation, and substantially improves classification for underrepresented emotion classes. However, our linguistic analysis reveals that synthetic text exhibits reduced vocabulary richness and fewer personal or temporally complex expressions than authentic posts. This work provides both a practical framework for responsible synthetic data generation and a critical perspective on its limitations, underscoring that the future of trustworthy AI depends on navigating the trade-offs between synthetic utility and real-world authenticity.

Multiple instance learning (MIL) has emerged as the dominant paradigm for whole slide image (WSI) analysis in computational pathology, achieving strong diagnostic performance through patch-level feature aggregation. However, existing MIL methods face critical limitations: (1) they rely on attention mechanisms that lack causal interpretability, and (2) they fail to integrate patient demographics (age, gender, race), leading to fairness concerns across diverse populations. These shortcomings hinder clinical translation, where algorithmic bias can exacerbate health disparities. We introduce \textbf{MeCaMIL}, a causality-aware MIL framework that explicitly models demographic confounders through structured causal graphs. Unlike prior approaches treating demographics as auxiliary features, MeCaMIL employs principled causal inference -- leveraging do-calculus and collider structures -- to disentangle disease-relevant signals from spurious demographic correlations. Extensive evaluation on three benchmarks demonstrates state-of-the-art performance across CAMELYON16 (ACC/AUC/F1: 0.939/0.983/0.946), TCGA-Lung (0.935/0.979/0.931), and TCGA-Multi (0.977/0.993/0.970, five cancer types). Critically, MeCaMIL achieves superior fairness -- demographic disparity variance drops by over 65% relative reduction on average across attributes, with notable improvements for underserved populations. The framework generalizes to survival prediction (mean C-index: 0.653, +0.017 over best baseline across five cancer types). Ablation studies confirm causal graph structure is essential -- alternative designs yield 0.048 lower accuracy and 4.2x times worse fairness. These results establish MeCaMIL as a principled framework for fair, interpretable, and clinically actionable AI in digital pathology. Code will be released upon acceptance.

ProbLog4Fairness: A Neurosymbolic Approach to Modeling and Mitigating Bias

Rik Adriaensen, Lucas Van Praet, Jessa Bekker +3

Operationalizing definitions of fairness is difficult in practice, as multiple definitions can be incompatible while each being arguably desirable. Instead, it may be easier to directly describe algorithmic bias through ad-hoc assumptions specific to a particular real-world task, e.g., based on background information on systemic biases in its context. Such assumptions can, in turn, be used to mitigate this bias during training. Yet, a framework for incorporating such assumptions that is simultaneously principled, flexible, and interpretable is currently lacking. Our approach is to formalize bias assumptions as programs in ProbLog, a probabilistic logic programming language that allows for the description of probabilistic causal relationships through logic. Neurosymbolic extensions of ProbLog then allow for easy integration of these assumptions in a neural network's training process. We propose a set of templates to express different types of bias and show the versatility of our approach on synthetic tabular datasets with known biases. Using estimates of the bias distortions present, we also succeed in mitigating algorithmic bias in real-world tabular and image data. We conclude that ProbLog4Fairness outperforms baselines due to its ability to flexibly model the relevant bias assumptions, where other methods typically uphold a fixed bias type or notion of fairness.

Cultural infrastructures, such as libraries, museums, theaters, and galleries, support learning, civic life, health, and local economies, yet access is uneven across cities. We present a novel, scalable, and open-data framework to measure spatial equity in cultural access. We map cultural infrastructures and compute a metric called Cultural Infrastructure Accessibility Score (CIAS) using exponential distance decay at fine spatial resolution, then aggregate the score per capita and integrate socio-demographic indicators. Interpretable tree-ensemble models with SHapley Additive exPlanation (SHAP) are used to explain associations between accessibility, income, density, and tract-level racial/ethnic composition. Results show a pronounced core-periphery gradient, where non-library cultural infrastructures cluster near urban cores, while libraries track density and provide broader coverage. Non-library accessibility is modestly higher in higher-income tracts, and library accessibility is slightly higher in denser, lower-income areas.

We introduce LiveSecBench, a continuously updated safety benchmark specifically for Chinese-language LLM application scenarios. LiveSecBench constructs a high-quality and unique dataset through a pipeline that combines automated generation with human verification. By periodically releasing new versions to expand the dataset and update evaluation metrics, LiveSecBench provides a robust and up-to-date standard for AI safety. In this report, we introduce our second release v251215, which evaluates across five dimensions (Public Safety, Fairness & Bias, Privacy, Truthfulness, and Mental Health Safety.) We evaluate 57 representative LLMs using an ELO rating system, offering a leaderboard of the current state of Chinese LLM safety. The result is available at https://livesecbench.intokentech.cn/.

The development of Artificial Intelligence (AI), including AI in Science (AIS), should be done following the principles of responsible AI. Progress in responsible AI is often quantified through evaluation metrics, yet there has been less work on assessing the robustness and reliability of the metrics themselves. We reflect on prior work that examines the robustness of fairness metrics for recommender systems as a type of AI application and summarise their key takeaways into a set of non-exhaustive guidelines for developing reliable metrics of responsible AI. Our guidelines apply to a broad spectrum of AI applications, including AIS.

Developing benchmark datasets for low-resource languages poses significant challenges, primarily due to the limited availability of native linguistic experts and the substantial time and cost involved in annotation. Given these challenges, Maithili is still underrepresented in natural language processing research. It is an Indo-Aryan language spoken by more than 13 million people in the Purvanchal region of India, valued for its rich linguistic structure and cultural significance. While sentiment analysis has achieved remarkable progress in high-resource languages, resources for low-resource languages, such as Maithili, remain scarce, often restricted to coarse-grained annotations and lacking interpretability mechanisms. To address this limitation, we introduce a novel dataset comprising 3,221 Maithili sentences annotated for sentiment polarity and accompanied by natural language justifications. Moreover, the dataset is carefully curated and validated by linguistic experts to ensure both label reliability and contextual fidelity. Notably, the justifications are written in Maithili, thereby promoting culturally grounded interpretation and enhancing the explainability of sentiment models. Furthermore, extensive experiments using both classical machine learning and state-of-the-art transformer architectures demonstrate the dataset's effectiveness for interpretable sentiment analysis. Ultimately, this work establishes the first benchmark for explainable affective computing in Maithili, thus contributing a valuable resource to the broader advancement of multilingual NLP and explainable AI.

Current methods for evaluating large language models (LLMs) typically focus on high-level tasks such as text generation, without targeting a particular AI application. This approach is not sufficient for evaluating LLMs for Responsible AI dimensions like fairness, since protected attributes that are highly relevant in one application may be less relevant in another. In this work, we construct a dataset that is driven by a real-world application (generate a plain-text product description, given a list of product features), parameterized by fairness attributes intersected with gendered adjectives and product categories, yielding a rich set of labeled prompts. We show how to use the data to identify quality, veracity, safety, and fairness gaps in LLMs, contributing a proposal for LLM evaluation paired with a concrete resource for the research community.

Recent research has focused on mitigating algorithmic bias in clustering by incorporating fairness constraints into algorithmic design. Notions such as disparate impact, community cohesion, and cost per population have been implemented to enforce equitable outcomes. Among these, group fairness (balance) ensures that each protected group is proportionally represented within every cluster. However, incorporating balance as a metric of fairness into spectral clustering algorithms has led to computational times that can be improved. This study aims to enhance the efficiency of spectral clustering algorithms by reformulating the constrained optimization problem using a new formulation derived from the Lagrangian method and the Sherman-Morrison-Woodbury (SMW) identity, resulting in the Fair-SMW algorithm. Fair-SMW employs three alternatives to the Laplacian matrix with different spectral gaps to generate multiple variations of Fair-SMW, achieving clustering solutions with comparable balance to existing algorithms while offering improved runtime performance. We present the results of Fair-SMW, evaluated using the Stochastic Block Model (SBM) to measure both runtime efficiency and balance across real-world network datasets, including LastFM, FacebookNet, Deezer, and German. We achieve an improvement in computation time that is twice as fast as the state-of-the-art, and also flexible enough to achieve twice as much balance.

We introduce NAEL (Non-Anthropocentric Ethical Logic), a novel ethical framework for artificial agents grounded in active inference and symbolic reasoning. Departing from conventional, human-centred approaches to AI ethics, NAEL formalizes ethical behaviour as an emergent property of intelligent systems minimizing global expected free energy in dynamic, multi-agent environments. We propose a neuro-symbolic architecture to allow agents to evaluate the ethical consequences of their actions in uncertain settings. The proposed system addresses the limitations of existing ethical models by allowing agents to develop context-sensitive, adaptive, and relational ethical behaviour without presupposing anthropomorphic moral intuitions. A case study involving ethical resource distribution illustrates NAEL's dynamic balancing of self-preservation, epistemic learning, and collective welfare.