Research Papers

In this paper, we study the problem of AI explanation of misinformation, where the goal is to identify explanation designs that help improve users' misinformation detection abilities and their overall user experiences. Our work is motivated by the limitations of current Explainable AI (XAI) approaches, which predominantly focus on content explanations that elucidate the linguistic features and sentence structures of the misinformation. To address this limitation, we explore various explanations beyond content explanation, such as "social explanation" that considers the broader social context surrounding misinformation, as well as a "combined explanation" where both the content and social explanations are presented in scenarios that are either aligned or misaligned with each other. To evaluate the comparative effectiveness of these AI explanations, we conduct two online crowdsourcing experiments in the COVID-19 (Study 1 on Prolific) and Politics domains (Study 2 on MTurk). Our results show that AI explanations are generally effective in aiding users to detect misinformation, with effectiveness significantly influenced by the alignment between content and social explanations. We also find that the order in which explanation types are presented - specifically, whether a content or social explanation comes first - can influence detection accuracy, with differences found between the COVID-19 and Political domains. This work contributes towards more effective design of AI explanations, fostering a deeper understanding of how different explanation types and their combinations influence misinformation detection.

Cognitive Science has profoundly shaped disciplines such as Artificial Intelligence (AI), Philosophy, Psychology, Neuroscience, Linguistics, and Culture. Many breakthroughs in AI trace their roots to cognitive theories, while AI itself has become an indispensable tool for advancing cognitive research. This reciprocal relationship motivates a comprehensive review of the intersections between AI and Cognitive Science. By synthesizing key contributions from both perspectives, we observe that AI progress has largely emphasized practical task performance, whereas its cognitive foundations remain conceptually fragmented. We argue that the future of AI within Cognitive Science lies not only in improving performance but also in constructing systems that deepen our understanding of the human mind. Promising directions include aligning AI behaviors with cognitive frameworks, situating AI in embodiment and culture, developing personalized cognitive models, and rethinking AI ethics through cognitive co-evaluation.

Synthetic images, audio, and video can now be generated and edited by Artificial Intelligence (AI). In particular, the malicious use of synthetic data has raised concerns about potential harms to cybersecurity, personal privacy, and public trust. Although AI-based detection tools exist to help identify synthetic content, their limitations often lead to user mistrust and confusion between real and fake content. This study examines the role of AI performance in influencing human trust and decision making in synthetic data identification. Through an online human subject experiment involving 400 participants, we examined how varying AI performance impacts human trust and dependence on AI in deepfake detection. Our findings indicate how participants calibrate their dependence on AI based on their perceived risk and the prediction results provided by AI. These insights contribute to the development of transparent and explainable AI systems that better support everyday users in mitigating the harms of synthetic media.

Reinforcement learning (RL) plays a crucial role in shaping the behavior of large language and reasoning models (LLMs/LRMs). However, it often produces brittle and unstable policies, leading to critical failures such as spurious reasoning, deceptive alignment, and instruction disobedience that undermine the trustworthiness and safety of LLMs/LRMs. Currently, these issues lack a unified theoretical explanation and are typically addressed using ad-hoc heuristics. This paper presents a rigorous mathematical framework for analyzing the stability of the mapping from a reward function to the optimal policy. We show that policy brittleness often stems from non-unique optimal actions, a common occurrence when multiple valid traces exist in a reasoning task. This theoretical lens provides a unified explanation for a range of seemingly disparate failures, reframing them as rational outcomes of optimizing rewards that may be incomplete or noisy, especially in the presence of action degeneracy. We extend this analysis from the fundamental single-reward setting to the more realistic multi-reward RL across diverse domains, showing how stability is governed by an "effective reward" aggregation mechanism. We also prove that entropy regularization restores policy stability at the cost of increased stochasticity. Our framework provides a unified explanation for recent empirical findings on deceptive reasoning, instruction-following trade-offs, and RLHF-induced sophistry, and is further validated through perturbation experiments in multi-reward RL. This work advances policy-stability analysis from empirical heuristics towards a principled theory, offering essential insights for designing safer and more trustworthy AI systems.

Underwater image enhancement is vital for marine conservation, particularly coral reef monitoring. However, AI-based enhancement models often face dataset bias, high computational costs, and lack of transparency, leading to potential misinterpretations. This paper introduces EBA-AI, an ethics-guided bias-aware AI framework to address these challenges. EBA-AI leverages CLIP embeddings to detect and mitigate dataset bias, ensuring balanced representation across varied underwater environments. It also integrates adaptive processing to optimize energy efficiency, significantly reducing GPU usage while maintaining competitive enhancement quality. Experiments on LSUI400, Oceanex, and UIEB100 show that while PSNR drops by a controlled 1.0 dB, computational savings enable real-time feasibility for large-scale marine monitoring. Additionally, uncertainty estimation and explainability techniques enhance trust in AI-driven environmental decisions. Comparisons with CycleGAN, FunIEGAN, RAUNENet, WaterNet, UGAN, PUGAN, and UTUIE validate EBA-AI's effectiveness in balancing efficiency, fairness, and interpretability in underwater image processing. By addressing key limitations of AI-driven enhancement, this work contributes to sustainable, bias-aware, and computationally efficient marine conservation efforts. For interactive visualizations, animations, source code, and access to the preprint, visit: https://lyessaadsaoud.github.io/EBA-AI/

Heart disease continues to pose a critical worldwide health issue, more specifically in areas with insufficient access to healthcare infrastructure and diagnostic systems. Conventional diagnostic approaches often fall short in accurately detecting and managing heart disease risks, resulting in unfavorable outcomes. Machine learning presents a powerful means to boost the precision and reliability of cardiovascular disease prognosis and diagnosis. In this research, we introduced a unified approach incorporating classification techniques for detecting heart disease and regression techniques for forecasting associated risks. The analysis utilized the dataset, named Heart Disease, containing 1,035 instances. To mitigate the problem of data disproportion, the SMOTE was implemented, producing 100,000 additional synthetic samples. Evaluation metrics such as F1-score, recall, precision, accuracy, MAE, RMSE, MSE, and R2 were adopted to evaluate the performance of the models. Among the classification algorithms, Random Forest delivered the most notable results, attaining an accuracy of 0.972 on actual data and 0.976 on artificially generated data. For prediction modeling, for both synthetic and real samples, linear regression produced the best R2 values of 0.992 and 0.984, respectively, along with the least amount of measurement errors. Furthermore, Explainable AI methods were utilized to improve the comprehensibility of the model outcomes. This paper emphasizes the transformative capabilities of machine learning for diagnosing cardiovascular disease and estimating risk levels, thereby supporting timely interventions and enhancing clinical settings.

Quantifying Cross-Attention Interaction in Transformers for Interpreting TCR-pMHC Binding

Jiarui Li, Zixiang Yin, Haley Smith +3

CD8+ "killer" T cells and CD4+ "helper" T cells play a central role in the adaptive immune system by recognizing antigens presented by Major Histocompatibility Complex (pMHC) molecules via T Cell Receptors (TCRs). Modeling binding between T cells and the pMHC complex is fundamental to understanding basic mechanisms of human immune response as well as in developing therapies. While transformer-based models such as TULIP have achieved impressive performance in this domain, their black-box nature precludes interpretability and thus limits a deeper mechanistic understanding of T cell response. Most existing post-hoc explainable AI (XAI) methods are confined to encoder-only, co-attention, or model-specific architectures and cannot handle encoder-decoder transformers used in TCR-pMHC modeling. To address this gap, we propose Quantifying Cross-Attention Interaction (QCAI), a new post-hoc method designed to interpret the cross-attention mechanisms in transformer decoders. Quantitative evaluation is a challenge for XAI methods; we have compiled TCR-XAI, a benchmark consisting of 274 experimentally determined TCR-pMHC structures to serve as ground truth for binding. Using these structures we compute physical distances between relevant amino acid residues in the TCR-pMHC interaction region and evaluate how well our method and others estimate the importance of residues in this region across the dataset. We show that QCAI achieves state-of-the-art performance on both interpretability and prediction accuracy under the TCR-XAI benchmark.

Healthcare 5.0 integrates Artificial Intelligence (AI), the Internet of Things (IoT), real-time monitoring, and human-centered design toward personalized medicine and predictive diagnostics. However, the increasing reliance on interconnected medical technologies exposes them to cyber threats. Meanwhile, current AI-driven cybersecurity models often neglect biomedical data, limiting their effectiveness and interpretability. This study addresses this gap by applying eXplainable AI (XAI) to a Healthcare 5.0 dataset that integrates network traffic and biomedical sensor data. Classification outputs indicate that XGBoost achieved 99% F1-score for benign and data alteration, and 81% for spoofing. Explainability findings reveal that network data play a dominant role in intrusion detection whereas biomedical features contributed to spoofing detection, with temperature reaching a Shapley values magnitude of 0.37.

Cooperative game theory has become a cornerstone of post-hoc interpretability in machine learning, largely through the use of Shapley values. Yet, despite their widespread adoption, Shapley-based methods often rest on axiomatic justifications whose relevance to feature attribution remains debatable. In this paper, we revisit cooperative game theory from an interpretability perspective and argue for a broader and more principled use of its tools. We highlight two general families of efficient allocations, the Weber and Harsanyi sets, that extend beyond Shapley values and offer richer interpretative flexibility. We present an accessible overview of these allocation schemes, clarify the distinction between value functions and aggregation rules, and introduce a three-step blueprint for constructing reliable and theoretically-grounded feature attributions. Our goal is to move beyond fixed axioms and provide the XAI community with a coherent framework to design attribution methods that are both meaningful and robust to shifting methodological trends.

Despite promising developments in Explainable Artificial Intelligence, the practical value of XAI methods remains under-explored and insufficiently validated in real-world settings. Robust and context-aware evaluation is essential, not only to produce understandable explanations but also to ensure their trustworthiness and usability for intended users, but tends to be overlooked because of no clear guidelines on how to design an evaluation with users. This study addresses this gap with two main goals: (1) to develop a framework of well-defined, atomic properties that characterise the user experience of XAI in healthcare; and (2) to provide clear, context-sensitive guidelines for defining evaluation strategies based on system characteristics. We conducted a systematic review of 82 user studies, sourced from five databases, all situated within healthcare settings and focused on evaluating AI-generated explanations. The analysis was guided by a predefined coding scheme informed by an existing evaluation framework, complemented by inductive codes developed iteratively. The review yields three key contributions: (1) a synthesis of current evaluation practices, highlighting a growing focus on human-centred approaches in healthcare XAI; (2) insights into the interrelations among explanation properties; and (3) an updated framework and a set of actionable guidelines to support interdisciplinary teams in designing and implementing effective evaluation strategies for XAI systems tailored to specific application contexts.

Evaluating feature attribution methods represents a critical challenge in explainable AI (XAI), as researchers typically rely on perturbation-based metrics when ground truth is unavailable. However, recent work reveals that these evaluation metrics can show different performance across predicted classes within the same dataset. These "class-dependent evaluation effects" raise questions about whether perturbation analysis reliably measures attribution quality, with direct implications for XAI method development and evaluation trustworthiness. We investigate under which conditions these class-dependent effects arise by conducting controlled experiments with synthetic time series data where ground truth feature locations are known. We systematically vary feature types and class contrasts across binary classification tasks, then compare perturbation-based degradation scores with ground truth-based precision-recall metrics using multiple attribution methods. Our experiments demonstrate that class-dependent effects emerge with both evaluation approaches, even in simple scenarios with temporally localized features, triggered by basic variations in feature amplitude or temporal extent between classes. Most critically, we find that perturbation-based and ground truth metrics frequently yield contradictory assessments of attribution quality across classes, with weak correlations between evaluation approaches. These findings suggest that researchers should interpret perturbation-based metrics with care, as they may not always align with whether attributions correctly identify discriminating features. By showing this disconnect, our work points toward reconsidering what attribution evaluation actually measures and developing more rigorous evaluation methods that capture multiple dimensions of attribution quality.

Infertility has a considerable impact on individuals' quality of life, affecting them socially and psychologically, with projections indicating a rise in the upcoming years. In vitro fertilization (IVF) emerges as one of the primary techniques within economically developed nations, employed to address the rising problem of low fertility. Expert embryologists conventionally grade embryos by reviewing blastocyst images to select the most optimal for transfer, yet this process is time-consuming and lacks efficiency. Blastocyst images provide a valuable resource for assessing embryo viability. In this study, we introduce an explainable artificial intelligence (XAI) framework for classifying embryos, employing a fusion of convolutional neural network (CNN) and long short-term memory (LSTM) architecture, referred to as CNN-LSTM. Utilizing deep learning, our model achieves high accuracy in embryo classification while maintaining interpretability through XAI.