Research Papers

As modern science becomes increasingly data-intensive, the ability to analyze and visualize large-scale, complex datasets is critical to accelerating discovery. However, many domain scientists lack the programming expertise required to develop custom data analysis workflows, creating barriers to timely and effective insight. Large language models (LLMs) offer a promising solution by generating executable code from natural language descriptions. In this paper, we investigate the trustworthiness of open-source LLMs in autonomously producing Python scripts for scientific data analysis and visualization. We construct a benchmark suite of domain-inspired prompts that reflect real-world research tasks and systematically evaluate the executability and correctness of the generated code. Our findings show that, without human intervention, the reliability of LLM-generated code is limited, with frequent failures caused by ambiguous prompts and the models' insufficient understanding of domain-specific contexts. To address these challenges, we design and assess three complementary strategies: data-aware prompt disambiguation, retrieval-augmented prompt enhancement, and iterative error repair. While these methods significantly improve execution success rates and output quality, further refinement is needed. This work highlights both the promise and current limitations of LLM-driven automation in scientific workflows and introduces actionable techniques and a reusable benchmark for building more inclusive, accessible, and trustworthy AI-assisted research tools.

The 2nd Workshop on Human-Centered Recommender Systems

Kaike Zhang, Jiakai Tang, Du Su +6

Recommender systems shape how people discover information, form opinions, and connect with society. Yet, as their influence grows, traditional metrics, e.g., accuracy, clicks, and engagement, no longer capture what truly matters to humans. The workshop on Human-Centered Recommender Systems (HCRS) calls for a paradigm shift from optimizing engagement toward designing systems that truly understand, involve, and benefit people. It brings together researchers in recommender systems, human-computer interaction, AI safety, and social computing to explore how human values, e.g., trust, safety, fairness, transparency, and well-being, can be integrated into recommendation processes. Centered around three thematic axes-Human Understanding, Human Involvement, and Human Impact-HCRS features keynotes, panels, and papers covering topics from LLM-based interactive recommenders to societal welfare optimization. By fostering interdisciplinary collaboration, HCRS aims to shape the next decade of responsible and human-aligned recommendation research.

Large language models (LLMs) show promise in automating clinical diagnosis, yet their non-transparent decision-making and limited alignment with diagnostic standards hinder trust and clinical adoption. We address this challenge by proposing a two-stage diagnostic framework that enhances transparency, trustworthiness, and reliability. First, we introduce Evidence-Guided Diagnostic Reasoning (EGDR), which guides LLMs to generate structured diagnostic hypotheses by interleaving evidence extraction with logical reasoning grounded in DSM-5 criteria. Second, we propose a Diagnosis Confidence Scoring (DCS) module that evaluates the factual accuracy and logical consistency of generated diagnoses through two interpretable metrics: the Knowledge Attribution Score (KAS) and the Logic Consistency Score (LCS). Evaluated on the D4 dataset with pseudo-labels, EGDR outperforms direct in-context prompting and Chain-of-Thought (CoT) across five LLMs. For instance, on OpenBioLLM, EGDR improves accuracy from 0.31 (Direct) to 0.76 and increases DCS from 0.50 to 0.67. On MedLlama, DCS rises from 0.58 (CoT) to 0.77. Overall, EGDR yields up to +45% accuracy and +36% DCS gains over baseline methods, offering a clinically grounded, interpretable foundation for trustworthy AI-assisted diagnosis.

Foundation models hold promise for specialized medical imaging tasks, though their effectiveness in breast imaging remains underexplored. This study leverages BiomedCLIP as a foundation model to address challenges in model generalization. BiomedCLIP was adapted for automated BI-RADS breast density classification using multi-modality mammographic data (synthesized 2D images, digital mammography, and digital breast tomosynthesis). Using 96,995 images, we compared single-modality (s2D only) and multi-modality training approaches, addressing class imbalance through weighted contrastive learning. Both approaches achieved similar accuracy (multi-modality: 0.74, single-modality: 0.73), with the multi-modality model offering broader applicability across different imaging modalities and higher AUC values consistently above 0.84 across BI-RADS categories. External validation on the RSNA and EMBED datasets showed strong generalization capabilities (AUC range: 0.80-0.93). GradCAM visualizations confirmed consistent and clinically relevant attention patterns, highlighting the models interpretability and robustness. This research underscores the potential of foundation models for breast imaging applications, paving the way for future extensions for diagnostic tasks.

The task of weed detection is an essential element of precision agriculture since accurate species identification allows a farmer to selectively apply herbicides and fits into sustainable agriculture crop management. This paper proposes a hybrid deep learning framework recipe for weed detection that utilizes Convolutional Neural Networks (CNNs), Vision Transformers (ViTs), and Graph Neural Networks (GNNs) to build robustness to multiple field conditions. A Generative Adversarial Network (GAN)-based augmentation method was imposed to balance class distributions and better generalize the model. Further, a self-supervised contrastive pre-training method helps to learn more features from limited annotated data. Experimental results yield superior results with 99.33% accuracy, precision, recall, and F1-score on multi-benchmark datasets. The proposed model architecture enables local, global, and relational feature representations and offers high interpretability and adaptability. Practically, the framework allows real-time, efficient deployment of edge devices for automated weed detecting, reducing over-reliance on herbicides and providing scalable, sustainable precision-farming options.

Proteins perform essential biological functions, and accurate classification of their sequences is critical for understanding structure-function relationships, enzyme mechanisms, and molecular interactions. This study presents a deep learning-based framework for functional group classification of protein sequences derived from the Protein Data Bank (PDB). Four architectures were implemented: Convolutional Neural Network (CNN), Bidirectional Long Short-Term Memory (BiLSTM), CNN-BiLSTM hybrid, and CNN with Attention. Each model was trained using k-mer integer encoding to capture both local and long-range dependencies. Among these, the CNN achieved the highest validation accuracy of 91.8%, demonstrating the effectiveness of localized motif detection. Explainable AI techniques, including Grad-CAM and Integrated Gradients, were applied to interpret model predictions and identify biologically meaningful sequence motifs. The discovered motifs, enriched in histidine, aspartate, glutamate, and lysine, represent amino acid residues commonly found in catalytic and metal-binding regions of transferase enzymes. These findings highlight that deep learning models can uncover functionally relevant biochemical signatures, bridging the gap between predictive accuracy and biological interpretability in protein sequence analysis.

This third international workshop on explainable AI for the Arts (XAIxArts) brought together a community of researchers in HCI, Interaction Design, AI, explainable AI (XAI), and digital arts to explore the role of XAI for the Arts. Workshop held at the 17th ACM Conference on Creativity and Cognition (C&C 2025), online.

The implementation of agentic AI systems has the potential of providing more helpful AI systems in a variety of applications. These systems work autonomously towards a defined goal with reduced external control. Despite their potential, one of their flaws is the insufficient reliability which makes them especially unsuitable for high-risk domains such as healthcare or process industry. Unreliable systems pose a risk in terms of unexpected behavior during operation and mitigation techniques are needed. In this work, we derive the main reliability challenges of agentic AI systems during operation based on their characteristics. We draw the connection to traditional AI systems and formulate a fundamental reliability challenge during operation which is inherent to traditional and agentic AI systems. As our main contribution, we propose a two-layered reliability monitoring framework for agentic AI systems which consists of a out-of-distribution detection layer for novel inputs and AI transparency layer to reveal internal operations. This two-layered monitoring approach gives a human operator the decision support which is needed to decide whether an output is potential unreliable or not and intervene. This framework provides a foundation for developing mitigation techniques to reduce risk stemming from uncertain reliability during operation.

Intrusion Detection Systems (IDS) play a vital role in modern cybersecurity frameworks by providing a primary defense mechanism against sophisticated threat actors. In this paper, we propose an explainable intrusion detection framework that integrates Recursive Feature Elimination (RFE) with Random Forest (RF) to enhance detection of Advanced Persistent Threats (APTs). By using CICIDS2017 dataset, the approach begins with comprehensive data preprocessing and narrows down the most significant features via RFE. A Random Forest (RF) model was trained on the refined feature set, with SHapley Additive exPlanations (SHAP) used to interpret the contribution of each selected feature. Our experiment demonstrates that the explainable RF-RFE achieved a detection accuracy of 99.9%, reducing false positive and computational cost in comparison to traditional classifiers. The findings underscore the effectiveness of integrating explainable AI and feature selection to develop a robust, transparent, and deployable IDS solution.

Explainable AI (XAI) for Speech Emotion Recognition (SER) is critical for building transparent, trustworthy models. Current saliency-based methods, adapted from vision, highlight spectrogram regions but fail to show whether these regions correspond to meaningful acoustic markers of emotion, limiting faithfulness and interpretability. We propose a framework that overcomes these limitations by quantifying the magnitudes of cues within salient regions. This clarifies "what" is highlighted and connects it to "why" it matters, linking saliency to expert-referenced acoustic cues of speech emotions. Experiments on benchmark SER datasets show that our approach improves explanation quality by explicitly linking salient regions to theory-driven speech emotions expert-referenced acoustics. Compared to standard saliency methods, it provides more understandable and plausible explanations of SER models, offering a foundational step towards trustworthy speech-based affective computing.

Machine learning is an essential tool for optimizing industrial quality control processes. However, the complexity of machine learning models often limits their practical applicability due to a lack of interpretability. Additionally, many industrial machines lack comprehensive sensor technology, making data acquisition incomplete and challenging. Explainable Artificial Intelligence offers a solution by providing insights into model decision-making and identifying the most relevant features for classification. In this paper, we investigate the impact of feature reduction using XAI techniques on the quality classification of injection-molded parts. We apply SHAP, Grad-CAM, and LIME to analyze feature importance in a Long Short-Term Memory model trained on real production data. By reducing the original 19 input features to 9 and 6, we evaluate the trade-off between model accuracy, inference speed, and interpretability. Our results show that reducing features can improve generalization while maintaining high classification performance, with an small increase in inference speed. This approach enhances the feasibility of AI-driven quality control, particularly for industrial settings with limited sensor capabilities, and paves the way for more efficient and interpretable machine learning applications in manufacturing.

As Multi Agent Reinforcement Learning systems are used in safety critical applications. Understanding why agents make decisions and how they achieve collective behavior is crucial. Existing explainable AI methods struggle in multi agent settings. They fail to attribute collective outcomes to individuals, quantify emergent behaviors, or capture complex interactions. We present MACIE Multi Agent Causal Intelligence Explainer, a framework combining structural causal models, interventional counterfactuals, and Shapley values to provide comprehensive explanations. MACIE addresses three questions. First, each agent's causal contribution using interventional attribution scores. Second, system level emergent intelligence through synergy metrics separating collective effects from individual contributions. Third, actionable explanations using natural language narratives synthesizing causal insights. We evaluate MACIE across four MARL scenarios: cooperative, competitive, and mixed motive. Results show accurate outcome attribution, mean phi_i equals 5.07, standard deviation less than 0.05, detection of positive emergence in cooperative tasks, synergy index up to 0.461, and efficient computation, 0.79 seconds per dataset on CPU. MACIE uniquely combines causal rigor, emergence quantification, and multi agent support while remaining practical for real time use. This represents a step toward interpretable, trustworthy, and accountable multi agent AI.