Research Papers

Artificial intelligence has strong potential to support clinical decision-making, yet its adoption in healthcare remains limited due to a lack of trust. Uncertainty estimation can signal unreliable predictions, and explainable AI (XAI) can clarify how predictions are made but existing methods treat them separately, providing no feature-level insight into why a prediction is uncertain or which tests to prioritize to reduce it. To address this gap, we propose explainable uncertainty estimation, which unifies uncertainty estimation and XAI to both quantify uncertainty and explain feature-level contributions. We introduce the Expected Gradients Reconstruction Uncertainty Estimate (egRUE), which incorporates prediction explanations into its uncertainty computation and decomposes uncertainty into feature-wise contributions. We prove theoretical properties of egRUE and show through experiments that it improves reliability and interpretability compared to existing methods. A user study with medical experts further demonstrates that egRUE's explanations improve calibrated trust over uncertainty scores alone, increasing confidence in correct predictions and reducing confidence in incorrect ones. By combining prediction uncertainty with feature-level explanations, egRUE strengthens decision-making support in safety-critical healthcare settings, clarifying both when predictions may be unreliable and which features drive that uncertainty.

When Robots Mishear Us: Mapping the Safety Risks of Voice-Controlled Embodied AI

Sihan Jia, Oliver Lemon

We investigate whether automatic speech recognition (ASR) errors in user input can lead to unsafe outputs from Embodied AI (EAI) models. We find that ASR errors can lead to harmful instructions being accepted and executed by EAI models, thereby reducing safety. We simulate ASR errors and combine them with existing safety benchmarks (SafeAgentBench and POEX) to evaluate how different errors affect embodied AI safety. We find that some of them preserve semantic structure but increase harmful ambiguity, while others weaken the model refusal behaviour and allow unsafe plans to be generated and executed. We show that in some cases automatic correction of ASR errors can reduce the risk, but this is not always effective. Overall, we show that ASR errors lead to significant safety risks for embodied AI.

Computational pathology (CompPath) is transforming medicine by leveraging artificial intelligence (AI) algorithms to support diagnosis, prognosis, and treatment prediction from gigapixel whole-slide images. Clinical adoption is progressing, but is constrained by concerns about safety, accountability, and regulatory oversight in high-stakes clinical environments. Explainable AI (XAI) systems hold promise for building trust and enabling verification, yet the literature remains fragmented due to inconsistent terminology, overlapping methodological families, ad hoc validation, and current reviews. This review aims to formalize XAI methods in CompPath through the: i) introduction of a pathology-centric vocabulary comprising seven core terms; ii) development of a taxonomy across methodological families and three orthogonal axes (stage, type, scope); and iii) establishment of a task-driven framework that maps five clinical questions to recommended methods, method evaluation, and deployment context. Five key gaps between current XAI capabilities and clinical deployment are identified, and actionable steps are proposed to advance XAI for CompPath.

Ensuring a safe virtual reality (VR) experience requires systems that can predict and respond when users lose their balance. Although prior work has examined fall prediction and motion sickness, many approaches are regression-based and postural state classification remains less explored. This study compares machine learning (ML) and deep learning (DL) models for classifying postural states in VR under visual perturbations. We used a multimodal dataset containing kinematic, electromyographic (EMG), and electrodermal activity (EDA) signals. The data were prepared for a binary task to distinguish balanced from imbalanced postural states, and participant-wise downsampling addressed class imbalance. All models were evaluated with Leave-One-Participant-Out (LOPO) cross-validation to test generalization to unseen participants. Among the models, the Mamba-inspired CNN (MI-CNN) achieved the highest accuracy of 96.76%. SHapley Additive exPlanations (SHAP) analysis improved interpretability and identified the most influential classification factors. The SHAP results showed that kinematic features were dominant, indicating that body-motion patterns are informative for detecting imbalance in VR. We also evaluated MI-CNN using only the top two-thirds of features ranked by SHAP importance. Despite a 33% reduction in input dimensionality, the model maintained performance, achieving 0.957 accuracy and 0.957 F1-score, with about a 1% decrease compared with the full-feature model. These findings suggest that multimodal sensing, temporal deep learning, and explainable AI can support reliable classification of balance-related instability in VR. Accurate recognition of imbalanced postural states may raise awareness of fall risk and guide safer, adaptive VR systems that respond to instability while improving user safety and experience. Code is available at: https://github.com/NipaAnjum/MI-CNN.

Generative text-to-image (T2I) systems are increasingly adopted in creative practice, yet their normative behaviors remain underexplored from the perspective of creative practitioners. In this workshop paper, we present a within-subject study with 14 creative practitioners using Stable Diffusion to create illustration from two tasks of differing specificity. We investigate whether and how practitioners perceive normative behavior in a T2I system and how it impacts their creative process depending on task specificity. Our findings show that participants perceived normative behavior through invariant patterns, stereotypical output, and unsolicited omission or addition of details. These experiences led to feelings of disempowerment and creative compromise. We discuss implications for XAIxArts, including prompt transparency and artist empowerment in creative contexts.

In the realm of Explainable AI, classification results are often explained via counterfactuals (CFs for short), which are (ideally small) perturbations to an instance that lead to a change of classification label. Such CFs may serve as explanations for the prediction, pinpointing the features that were important. Existing explainability solutions typically aim at minimizing the distance of CFs from the original instance so that they are specific to it, and/or maximizing the diversity of CFs to cover multiple facets of the reasons underlying the prediction. In this paper, we note that in pursuing these aims, state-of-the-art explainability solutions may (and often do) yield counterfactual explanations that do not correspond to realistic instances. This limits their applicability and usefulness in practice. To remedy this, we combine ideas from Explainable AI with ideas from data management. Specifically, we capture realism of CFs via logical constraints that hold with respect to a dataset of examples (e.g., training set); the class of such constraints that we focus on is that of denial constraints, extensively studied in the context of relational databases. Algorithmically, we then combine explainable AI solutions to yield CFs, with ideas from data cleaning that we adapt to this unique setting, to transform CFs into realistic ones. Extensive experiments across four datasets validate that our solutions achieve realism with relatively minor compromise in terms of distance and diversity. They further validate that the dedicated optimizations that we have developed to speed up the search for CFs are indeed highly effective.

Finetuning has become the gold standard for refining existing behaviors and inducing new ones in language models, yet it often remains unclear exactly which behaviors emerge during this process. As models grow ever more capable, understanding finetuning better becomes increasingly important, particularly since unwanted behaviors may arise during finetuning. In this paper, we introduce Diff Mining, a simple yet effective framework for identifying what a finetuned model has learned by comparing its logits to those of its base model. Diff Mining effectively surfaces salient tokens that are amplified in the finetuned model, serving as a fingerprint of its training -- even on text unrelated to the finetuning domain. Unlike many existing model diffing methods which require model internals, Diff Mining only needs access to output logits and scales to large models. The framework consists of two modular stages: (i) extracting per-context logit differences between the finetuned and base models on a reference corpus, and (ii) aggregating the resulting signals to construct an interpretable token set representing the finetune. For aggregation, we explore both a simple Top-K frequency method and a Non-negative Matrix Factorization (NMF)-based approach for disentangling multiple finetuning objectives into distinct token clusters. Empirically, Diff Mining succeeds across diverse settings: on finetune domain detection, it significantly outperforms state-of-the-art model diffing methods both in identifying relevant tokens and in downstream performance when an interpretability agent is given access to the extracted token set; on models with injected biases, it identifies more than one third of the biases without targeted probing. Overall, our framework shows promise in developing auditing tools to detect finetuning objectives.

As generative AI (genAI) systems become embedded in education, employment, healthcare, and creative industries, the impact and engagement among marginalized groups have become both a widespread discourse and a focus in scholarly research. As a starting point, we examine public discourse and empirical research to explore the impact of genAI systems on Black communities. We conducted a systematic literature review (SLR) of 91 empirical papers alongside a media discourse frame analysis of 28 public resources, applying Entman's framing theory to map how each corpus defines problems, attributes causes, and proposes treatments. Our SLR reveals that scholarly research concentrates heavily on technical bias detection, reducing Blackness to measurable variables rather than engaging with cultural practices, structural conditions, or Black knowledge systems. Our frame analysis reveals that public discourse attributes genAI-related harm to historical and systemic forces, while scholarly research stops its causal accounts at the dataset and its treatment recommendations at technical reform. We demonstrate that this misalignment is structurally produced: anti-Blackness operates simultaneously across both registers, generating a shared evacuation of Black epistemic agency. We argue for frame analysis as an AI ethics methodology capable of surfacing what technical evaluation forecloses.

Postpartum depression (PPD) poses a major burden on maternal and child health, especially in low- and middle-income countries where prevalence exceeds 19%. Despite advancements in machine learning for PPD prediction, current approaches are limited by opaque global explanations that lack clinical usefulness at the patient level, unstable feature selection, and poor generalization under class imbalance. We propose SAGE, a Stability-Aware Graph-Based Ensemble feature selection system that incorporates both local explainable AI and a genetically optimized artificial neural network (GA-ANN). Using a primary cohort of 766 postpartum women, SAGE combines information-theoretic relevance, PCA-based structure, and graph-based interactions with bootstrap stability weighting to identify robust and non-redundant predictors. The GA-ANN architecture, optimized using a genetic algorithm and enhanced with GAN based oversampling, achieved strong performance with 87.96% accuracy, 86.32% F1 score, and 0.88 AUC using only 16 features, outperforming baseline and other feature selection methods. Psychological and socioeconomic factors such as EPDS score, PHQ-9 score, feelings about motherhood, and abuse history are the main predictors, while demographic factors have less influence. The LIME-based explanations allow instance-based insight into selected features from the graph, enabling personalized risk assessment. The findings make SAGE a scalable, interpretable, and clinical tool for early identification of PPD in health-care limited resources.

Explainable AI (XAI) research has produced a plethora of explanation techniques, yet user studies repeatedly show that available explanations are not effective in practice. We argue that, given the siloed nature of conventional XAI, users are struggling to select the appropriate XAI technique. Viewing XAI through a philosophical lens, we offer a formalization of what we call the selection problem: the systematic failure of XAI interfaces to bridge the gap between a user's natural-language uncertainty and the explanation technique that resolves it. Following a logical premise-conclusion format, we show that conventional interfaces require users to translate their uncertainty into a technique selection, a challenging prerequisite to meet. We also propose a structural solution: a multi-agent LLM orchestration tool that translates the user's query to the proper XAI explanation technique. We provide an example of how this structural solution could be instantiated to address the selection problem.

Financial fraud detection relies heavily on centralized machine learning models. This creates serious data privacy risks. Federated Learning (FL) decentralizes data processing, but financial regulations still require models to be transparent. This means using Explainable AI (XAI) tools such as TreeSHAP. Recent cybersecurity research shows a problem with this approach. Sharing high-fidelity SHAP explanations exposes the federated network to Membership Inference Attacks (MIAs). This dissertation proposes and evaluates DP-FedSHAP. It is a new architecture that applies client-level differential privacy only to post-hoc TreeSHAP vectors. It is compared against a Weight-Level DP baseline, which perturbs the trained model directly instead. Using the highly imbalanced IEEE-CIS Fraud Detection dataset, this study measures the trade-off between explanation fidelity, privacy preservation, and the model's Area Under the Precision-Recall Curve (AUPRC).

Multimodal neuroimaging combining structural MRI and positron emission tomography (PET) captures complementary structure-function relationships across the Alzheimer's disease (AD) continuum, yet existing artificial intelligence systems produce a single diagnostic label without quantifying which imaging modality drove that decision for a specific patient. We introduce the Modality Contribution Network (MCNet) and the Modality Contribution Score (MCS), the first per-patient attribution framework quantifying the shift in modality dominance from structural atrophy to amyloid and metabolic dysfunction across the cognitively normal to MCI to AD continuum. MCS is normalised to unity per subject via modality ablation (MCS_MRI_i + MCS_PET_i = 1.0 for every subject i), providing an interpretable, clinically actionable score that fluid biomarkers cannot supply. Applied to 327 ADNI-3 participants balanced across cognitively normal, mild cognitive impairment, and AD groups, MCNet achieved competitive three-class staging performance (AUC=0.881). The MCS revealed a statistically significant monotonic gradient (Kruskal-Wallis p<0.0001), with increasing PET dominance from cognitively normal (MCS_PET 0.412+/-0.229) through MCI (0.489+/-0.289) to AD (0.671+/-0.426), validated against amyloid SUVR (r=0.172, p=0.006) and FDG metabolic biomarkers (r=-0.287, p=0.0005) from separate imaging pipelines. External replication in 1,073 independent OASIS-3 subjects confirmed cross-cohort generalisability (H=166.99, p<0.0001, eta^2=0.156). A mechanistic comparison with SHAP demonstrated that ablation-based MCS captures clinically meaningful modality dependence that deviation-based methods cannot. These findings position MCNet as a foundation for personalised imaging decisions, clinical trial stratification, and trustworthy AI in dementia care.