Research Papers

The relationship between humans and artificial intelligence is no longer science fiction -- it's a growing reality reshaping how we live and work. AI has moved beyond research labs into everyday life, powering customer service chats, personalizing travel, aiding doctors in diagnosis, and supporting educators. What makes this moment particularly compelling is AI's increasing collaborative nature. Rather than replacing humans, AI augments our capabilities -- automating routine tasks, enhancing decisions with data, and enabling creativity in fields like design, music, and writing. The future of work is shifting toward AI agents handling tasks autonomously, with humans as supervisors, strategists, and ethical stewards. This flips the traditional model: instead of humans using AI as a tool, intelligent agents will operate independently within constraints, managing everything from scheduling and customer service to complex workflows. Humans will guide and fine-tune these agents to ensure alignment with goals, values, and context. This shift offers major benefits -- greater efficiency, faster decisions, cost savings, and scalability. But it also brings risks: diminished human oversight, algorithmic bias, security flaws, and a widening skills gap. To navigate this transition, organizations must rethink roles, invest in upskilling, embed ethical principles, and promote transparency. This paper examines the technological and organizational changes needed to enable responsible adoption of AI-first systems -- where autonomy is balanced with human intent, oversight, and values.

Infertility has a considerable impact on individuals' quality of life, affecting them socially and psychologically, with projections indicating a rise in the upcoming years. In vitro fertilization (IVF) emerges as one of the primary techniques within economically developed nations, employed to address the rising problem of low fertility. Expert embryologists conventionally grade embryos by reviewing blastocyst images to select the most optimal for transfer, yet this process is time-consuming and lacks efficiency. Blastocyst images provide a valuable resource for assessing embryo viability. In this study, we introduce an explainable artificial intelligence (XAI) framework for classifying embryos, employing a fusion of convolutional neural network (CNN) and long short-term memory (LSTM) architecture, referred to as CNN-LSTM. Utilizing deep learning, our model achieves high accuracy in embryo classification while maintaining interpretability through XAI.

The United States and China are among the world's top players in the development of advanced artificial intelligence (AI) systems, and both are keen to lead in global AI governance and development. A look at U.S. and Chinese policy landscapes reveals differences in how the two countries approach the governance of general-purpose artificial intelligence (GPAI) systems. Three areas of divergence are notable for policymakers: the focus of domestic AI regulation, key principles of domestic AI regulation, and approaches to implementing international AI governance. As AI development continues, global conversation around AI has warned of global safety and security challenges posed by GPAI systems. Cooperation between the United States and China might be needed to address these risks, and understanding the implications of these differences might help address the broader challenges for international cooperation between the United States and China on AI safety and security.

Large Language Model (LLM) safeguards, which implement request refusals, have become a widely adopted mitigation strategy against misuse. At the intersection of adversarial machine learning and AI safety, safeguard red teaming has effectively identified critical vulnerabilities in state-of-the-art refusal-trained LLMs. However, in our view the many conference submissions on LLM red teaming do not, in aggregate, prioritize the right research problems. First, testing against clear product safety specifications should take a higher priority than abstract social biases or ethical principles. Second, red teaming should prioritize realistic threat models that represent the expanding risk landscape and what real attackers might do. Finally, we contend that system-level safety is a necessary step to move red teaming research forward, as AI models present new threats as well as affordances for threat mitigation (e.g., detection and banning of malicious users) once placed in a deployment context. Adopting these priorities will be necessary in order for red teaming research to adequately address the slate of new threats that rapid AI advances present today and will present in the very near future.

As large language models (LLMs) are increasingly deployed in high-stakes settings, their ability to refuse ethically sensitive prompts-such as those involving hate speech or illegal activities-has become central to content moderation and responsible AI practices. While refusal responses can be viewed as evidence of ethical alignment and safety-conscious behavior, recent research suggests that users may perceive them negatively. At the same time, automated assessments of model outputs are playing a growing role in both evaluation and training. In particular, LLM-as-a-Judge frameworks-in which one model is used to evaluate the output of another-are now widely adopted to guide benchmarking and fine-tuning. This paper examines whether such model-based evaluators assess refusal responses differently than human users. Drawing on data from Chatbot Arena and judgments from two AI judges (GPT-4o and Llama 3 70B), we compare how different types of refusals are rated. We distinguish ethical refusals, which explicitly cite safety or normative concerns (e.g., "I can't help with that because it may be harmful"), and technical refusals, which reflect system limitations (e.g., "I can't answer because I lack real-time data"). We find that LLM-as-a-Judge systems evaluate ethical refusals significantly more favorably than human users, a divergence not observed for technical refusals. We refer to this divergence as a moderation bias-a systematic tendency for model-based evaluators to reward refusal behaviors more than human users do. This raises broader questions about transparency, value alignment, and the normative assumptions embedded in automated evaluation systems.

The brain is a highly complex organ that manages many important tasks, including movement, memory and thinking. Brain-related conditions, like tumors and degenerative disorders, can be hard to diagnose and treat. Magnetic Resonance Imaging (MRI) serves as a key tool for identifying these conditions, offering high-resolution images of brain structures. Despite this, interpreting MRI scans can be complicated. This study tackles this challenge by conducting a comparative analysis of Vision Transformer (ViT) and Transfer Learning (TL) models such as VGG16, VGG19, Resnet50V2, MobilenetV2 for classifying brain diseases using MRI data from Bangladesh based dataset. ViT, known for their ability to capture global relationships in images, are particularly effective for medical imaging tasks. Transfer learning helps to mitigate data constraints by fine-tuning pre-trained models. Furthermore, Explainable AI (XAI) methods such as GradCAM, GradCAM++, LayerCAM, ScoreCAM, and Faster-ScoreCAM are employed to interpret model predictions. The results demonstrate that ViT surpasses transfer learning models, achieving a classification accuracy of 94.39%. The integration of XAI methods enhances model transparency, offering crucial insights to aid medical professionals in diagnosing brain diseases with greater precision.

This article addresses the challenge of modeling the amplitude of spatially indexed low frequency fluctuations (ALFF) in resting state functional MRI as a function of cortical structural features and a multi-task coactivation network in the Adolescent Brain Cognitive Development (ABCD) Study. It proposes a generative model that integrates effects of spatially-varying inputs and a network-valued input using deep neural networks to capture complex non-linear and spatial associations with the output. The method models spatial smoothness, accounts for subject heterogeneity and complex associations between network and spatial images at different scales, enables accurate inference of each images effect on the output image, and allows prediction with uncertainty quantification via Monte Carlo dropout, contributing to one of the first Explainable AI (XAI) frameworks for heterogeneous imaging data. The model is highly scalable to high-resolution data without the heavy pre-processing or summarization often required by Bayesian methods. Empirical results demonstrate its strong performance compared to existing statistical and deep learning methods. We applied the XAI model to the ABCD data which revealed associations between cortical features and ALFF throughout the entire brain. Our model performed comparably to existing methods in predictive accuracy but provided superior uncertainty quantification and faster computation, demonstrating its effectiveness for large-scale neuroimaging analysis. Open-source software in Python for XAI is available.

Integrating heterogeneous biomedical data including imaging, omics, and clinical records supports accurate diagnosis and personalised care. Graph-based models fuse such non-Euclidean data by capturing spatial and relational structure, yet clinical uptake requires regulator-ready interpretability. We present the first technical survey of interpretable graph based models for multimodal biomedical data, covering 26 studies published between Jan 2019 and Sep 2024. Most target disease classification, notably cancer and rely on static graphs from simple similarity measures, while graph-native explainers are rare; post-hoc methods adapted from non-graph domains such as gradient saliency, and SHAP predominate. We group existing approaches into four interpretability families, outline trends such as graph-in-graph hierarchies, knowledge-graph edges, and dynamic topology learning, and perform a practical benchmark. Using an Alzheimer disease cohort, we compare Sensitivity Analysis, Gradient Saliency, SHAP and Graph Masking. SHAP and Sensitivity Analysis recover the broadest set of known AD pathways and Gene-Ontology terms, whereas Gradient Saliency and Graph Masking surface complementary metabolic and transport signatures. Permutation tests show all four beat random gene sets, but with distinct trade-offs: SHAP and Graph Masking offer deeper biology at higher compute cost, while Gradient Saliency and Sensitivity Analysis are quicker though coarser. We also provide a step-by-step flowchart covering graph construction, explainer choice and resource budgeting to help researchers balance transparency and performance. This review synthesises the state of interpretable graph learning for multimodal medicine, benchmarks leading techniques, and charts future directions, from advanced XAI tools to under-studied diseases, serving as a concise reference for method developers and translational scientists.

Large Language Models (LLMs) have demonstrated human-like capabilities in language comprehension and generation, becoming active participants in social and cognitive domains. This study investigates whether LLMs exhibit personality-like traits and how these traits compare with human personality, focusing on the applicability of conventional personality assessment tools. A behavior-based approach was used across three empirical studies. Study 1 examined test-retest stability and found that LLMs show higher variability and are more input-sensitive than humans, lacking long-term stability. Based on this, we propose the Distributed Personality Framework, conceptualizing LLM traits as dynamic and input-driven. Study 2 analyzed cross-variant consistency in personality measures and found LLMs' responses were highly sensitive to item wording, showing low internal consistency compared to humans. Study 3 explored personality retention during role-playing, showing LLM traits are shaped by prompt and parameter settings. These findings suggest that LLMs express fluid, externally dependent personality patterns, offering insights for constructing LLM-specific personality frameworks and advancing human-AI interaction. This work contributes to responsible AI development and extends the boundaries of personality psychology in the age of intelligent systems.

Non-muscle-invasive bladder cancer (NMIBC) is a relentless challenge in oncology, with recurrence rates soaring as high as 70-80%. Each recurrence triggers a cascade of invasive procedures, lifelong surveillance, and escalating healthcare costs - affecting 460,000 individuals worldwide. However, existing clinical prediction tools remain fundamentally flawed, often overestimating recurrence risk and failing to provide personalized insights for patient management. In this work, we propose an interpretable deep learning framework that integrates vector embeddings and attention mechanisms to improve NMIBC recurrence prediction performance. We incorporate vector embeddings for categorical variables such as smoking status and intravesical treatments, allowing the model to capture complex relationships between patient attributes and recurrence risk. These embeddings provide a richer representation of the data, enabling improved feature interactions and enhancing prediction performance. Our approach not only enhances performance but also provides clinicians with patient-specific insights by highlighting the most influential features contributing to recurrence risk for each patient. Our model achieves accuracy of 70% with tabular data, outperforming conventional statistical methods while providing clinician-friendly patient-level explanations through feature attention. Unlike previous studies, our approach identifies new important factors influencing recurrence, such as surgical duration and hospital stay, which had not been considered in existing NMIBC prediction models.

As artificial intelligence (AI) systems rapidly gain autonomy, the need for robust responsible AI frameworks becomes paramount. This paper investigates how organizations perceive and adapt such frameworks amidst the emerging landscape of increasingly sophisticated agentic AI. Employing an interpretive qualitative approach, the study explores the lived experiences of AI professionals. Findings highlight that the inherent complexity of agentic AI systems and their responsible implementation, rooted in the intricate interconnectedness of responsible AI dimensions and the thematic framework (an analytical structure developed from the data), combined with the novelty of agentic AI, contribute to significant challenges in organizational adaptation, characterized by knowledge gaps, a limited emphasis on stakeholder engagement, and a strong focus on control. These factors, by hindering effective adaptation and implementation, ultimately compromise the potential for responsible AI and the realization of ROI.

Evaluation and Incident Prevention in an Enterprise AI Assistant

Akash V. Maharaj, David Arbour, Daniel Lee +6

Enterprise AI Assistants are increasingly deployed in domains where accuracy is paramount, making each erroneous output a potentially significant incident. This paper presents a comprehensive framework for monitoring, benchmarking, and continuously improving such complex, multi-component systems under active development by multiple teams. Our approach encompasses three key elements: (1) a hierarchical ``severity'' framework for incident detection that identifies and categorizes errors while attributing component-specific error rates, facilitating targeted improvements; (2) a scalable and principled methodology for benchmark construction, evaluation, and deployment, designed to accommodate multiple development teams, mitigate overfitting risks, and assess the downstream impact of system modifications; and (3) a continual improvement strategy leveraging multidimensional evaluation, enabling the identification and implementation of diverse enhancement opportunities. By adopting this holistic framework, organizations can systematically enhance the reliability and performance of their AI Assistants, ensuring their efficacy in critical enterprise environments. We conclude by discussing how this multifaceted evaluation approach opens avenues for various classes of enhancements, paving the way for more robust and trustworthy AI systems.